Charles P Schaefer
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Explore the profile of Charles P Schaefer including associated specialties, affiliations and a list of published articles.
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5
Citations
79
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Recent Articles
1.
Tome M, Jarvis C, Schaefer C, Jacobs L, Herndon J, Hunn K, et al.
J Cereb Blood Flow Metab
. 2018 Oct;
38(12):2209-2222.
PMID: 30346224
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity...
2.
Schaefer C, Arkwright N, Jacobs L, Jarvis C, Hunn K, Largent-Milnes T, et al.
PLoS One
. 2018 Feb;
13(2):e0192340.
PMID: 29414996
The rates of opioid prescription and use have continued to increase over the last few decades resulting in a greater number of opioid tolerant patients. Treatment of acute pain from...
3.
Schaefer C, Tome M, Davis T
Fluids Barriers CNS
. 2017 Nov;
14(1):32.
PMID: 29183383
Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use,...
4.
Tome M, Herndon J, Schaefer C, Jacobs L, Zhang Y, Jarvis C, et al.
J Cereb Blood Flow Metab
. 2016 Jul;
36(11):1913-1928.
PMID: 27466374
P-glycoprotein (PgP), a drug efflux pump in blood-brain barrier endothelial cells, is a major clinical obstacle for effective central nervous system drug delivery. Identifying PgP regulatory pathways that can be...
5.
Tome M, Schaefer C, Jacobs L, Zhang Y, Herndon J, Matty F, et al.
J Neurochem
. 2015 Apr;
134(2):200-10.
PMID: 25832806
Drug delivery to the brain for the treatment of pathologies with a CNS component is a significant clinical challenge. P-glycoprotein (PgP), a drug efflux pump in the endothelial cell membrane,...