Margaret C Frame
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Explore the profile of Margaret C Frame including associated specialties, affiliations and a list of published articles.
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104
Citations
6323
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Recent Articles
1.
Loftus A, Romano M, Phuong A, McKinnel B, Muir M, Furqan M, et al.
Dev Cell
. 2024 Sep;
59(24):3197-3212.e7.
PMID: 39326421
Glioblastoma (GBM) is driven by malignant neural stem-like cells that display extensive heterogeneity and phenotypic plasticity, which drive tumor progression and therapeutic resistance. Here, we show that the extracellular matrix-cell...
2.
Yaron-Barir T, Joughin B, Huntsman E, Kerelsky A, Cizin D, Cohen B, et al.
Nature
. 2024 May;
629(8014):1174-1181.
PMID: 38720073
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth. Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that...
3.
Titmarsh H, von Kriegsheim A, Wills J, OConnor R, Dhaliwal K, Frame M, et al.
Front Oncol
. 2023 Jul;
13:1194515.
PMID: 37397358
Introduction: The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and...
4.
Li Mow Chee F, Beernaert B, Griffith B, Loftus A, Kumar Y, Wills J, et al.
Nat Commun
. 2023 Mar;
14(1):1602.
PMID: 36959177
Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate...
5.
Webb E, Dodd G, Noskova M, Bullock E, Muir M, Frame M, et al.
Elife
. 2023 Mar;
12.
PMID: 36883731
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor...
6.
Millar F, Pennycuick A, Muir M, Quintanilla A, Hari P, Freyer E, et al.
Cell Rep
. 2022 Nov;
41(6):111596.
PMID: 36351380
Targeting early-stage lung cancer is vital to improve survival. However, the mechanisms and components of the early tumor suppressor response in lung cancer are not well understood. In this report,...
7.
Brunton V, Avizienyte E, Fincham V, Serrels B, Metcalf C, Sawyer T, et al.
Cancer Res
. 2022 Jul;
82(13):2500.
PMID: 35788292
No abstract available.
8.
Byron A, Griffith B, Herrero A, Loftus A, Koeleman E, Kogerman L, et al.
Nat Commun
. 2022 Jun;
13(1):3053.
PMID: 35650196
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear...
9.
Temps C, Lietha D, Webb E, Li X, Dawson J, Muir M, et al.
Cancer Res
. 2021 Aug;
81(21):5438-5450.
PMID: 34417202
Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition...
10.
Leach J, Vlahov N, Tsantoulis P, Ridgway R, Flanagan D, Gilroy K, et al.
Nat Commun
. 2021 Jun;
12(1):3464.
PMID: 34103493
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we describe...