Paul Timpson
Overview
Explore the profile of Paul Timpson including associated specialties, affiliations and a list of published articles.
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Articles
133
Citations
6305
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0
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Recent Articles
1.
Chambers C, Watakul S, Schofield P, Howell A, Zhu J, Tran A, et al.
Sci Adv
. 2025 Mar;
11(11):eadq4416.
PMID: 40073121
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known...
2.
Tang R, Tay S, Sharbeen G, Herrmann D, Youkhana J, Timpson P, et al.
Eur J Immunol
. 2025 Feb;
55(2):e202451215.
PMID: 39931761
Atypical chemokine receptors (ACKRs) are a subclass of chemokine receptors that internalise and degrade chemokines instead of eliciting chemotaxis. Scavenging by ACKRs reduces the local bioavailability of chemokines and can...
3.
Ju R, Falconer A, Schmidt C, Enriquez Martinez M, Dean K, Fiolka R, et al.
Nat Cell Biol
. 2024 Aug;
26(9):1520-1534.
PMID: 39160291
Cells migrating through complex three-dimensional environments experience considerable physical challenges, including tensile stress and compression. To move, cells need to resist these forces while also squeezing the large nucleus through...
4.
Pereira B, Ritchie S, Chambers C, Gordon K, Magenau A, Murphy K, et al.
Sci Adv
. 2024 Jul;
10(27):eadl1197.
PMID: 38959305
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic...
5.
Filipe E, Velayuthar S, Philp A, Nobis M, Latham S, Parker A, et al.
Adv Sci (Weinh)
. 2024 Apr;
11(23):e2307963.
PMID: 38602451
In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter...
6.
Samuel M, Lopez J, McGhee E, Croft D, Strachan D, Timpson P, et al.
Cancer Cell
. 2024 Feb;
42(2):317.
PMID: 38350422
No abstract available.
7.
Sugiyama Y, Reed D, Herrmann D, Lovicu F, Robinson M, Timpson P, et al.
Development
. 2024 Jan;
151(3).
PMID: 38240393
The spheroidal shape of the eye lens is crucial for precise light focusing onto the retina. This shape is determined by concentrically aligned, convexly elongated lens fiber cells along the...
8.
Sugiyama Y, Reed D, Herrmann D, Lovicu F, Robinson M, Timpson P, et al.
bioRxiv
. 2023 Dec;
PMID: 38106159
The spheroidal shape of the eye lens is critical for precise light focusing onto the retina. This shape is determined by concentrically aligned, convexly elongated lens fiber cells along the...
9.
Bhattacharyya N, Kyaw W, McDonald M, Dhenni R, Grootveld A, Xiao Y, et al.
Nat Protoc
. 2023 Oct;
18(12):3856-3880.
PMID: 37857852
Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial resolution in live animals. However, the endosteal bone compartment and underlying bone marrow pose unique challenges to optical imaging as light...
10.
Uceda-Castro R, Margarido A, Song J, de Gooijer M, Messal H, Chambers C, et al.
Sci Adv
. 2023 Oct;
9(42):eabp9530.
PMID: 37851804
Although initially successful, treatments with chemotherapy often fail because of the recurrence of chemoresistant metastases. Since these tumors develop after treatment, resistance is generally thought to occur in response to...