Marcos Guilherme da Cunha
Overview
Explore the profile of Marcos Guilherme da Cunha including associated specialties, affiliations and a list of published articles.
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15
Citations
225
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Recent Articles
1.
Mercaldi G, Bezerra E, Batista F, Tonoli C, Soprano A, Shimizu J, et al.
Sci Rep
. 2022 Nov;
12(1):18500.
PMID: 36323732
The nucleocapsid (N) protein plays critical roles in coronavirus genome transcription and packaging, representing a key target for the development of novel antivirals, and for which structural information on ligand...
2.
Rodrigues-Costa F, Slivinski J, Ioca L, Bertonha A, de Felicio R, da Cunha M, et al.
Bioorg Chem
. 2020 May;
100:103921.
PMID: 32464403
Enterococci are gram-positive, widespread nosocomial pathogens that in recent years have developed resistance to various commonly employed antibiotics. Since finding new infection-control agents based on secondary metabolites from organisms has...
3.
da Cunha M, Sardi J, Freires I, Franchin M, Rosalen P
Microb Pathog
. 2019 Nov;
139:103855.
PMID: 31706001
The discovery of new drug candidates, especially from natural products, remains a promising approach to overcome the alarmingly high microbial resistance rates. A major 4-phenyl coumarin named cinnamoyloxy-mammeisin (CNM) isolated...
4.
Nani B, Franchin M, Lazarini J, Freires I, da Cunha M, Bueno-Silva B, et al.
Phytother Res
. 2018 Jan;
32(4):750-754.
PMID: 29377427
Vestitol and neovestitol are bioactive isoflavonoids isolated from Brazilian red propolis, a unique Apis melifera type of propolis botanically originated from Dalbergia ecastophyllum. Although these molecules have relevant biological effects,...
5.
Franchin M, Freires I, Lazarini J, Nani B, da Cunha M, Colon D, et al.
Eur J Med Chem
. 2017 Jul;
153:49-55.
PMID: 28755848
Anti-Inflammatory drugs have been routinely used in the management of acute and chronic inflammatory conditions. Nevertheless, their undesirable side and adverse effects have encouraged the development of more selective, tolerable...
6.
da Cunha M, Ramos-Junior E, Franchin M, Taira T, Beutler J, Franco G, et al.
J Nat Prod
. 2017 Jun;
80(6):1893-1899.
PMID: 28570825
Bone-loss-related diseases such as rheumatoid arthritis, osteomyelitis, osteoporosis, and periodontitis are associated with high rates of morbidity worldwide. These disorders are characterized by an imbalance between the formation and activity...
7.
da Cunha M, Franco G, Franchin M, Beutler J, de Alencar S, Ikegaki M, et al.
Toxicol Lett
. 2016 Oct;
263:6-10.
PMID: 27773722
In silico and in vitro methodologies have been used as important tools in the drug discovery process, including from natural sources. The aim of this study was to predict pharmacokinetic...
8.
Franchin M, Rosalen P, da Cunha M, Leal Silva R, Colon D, Shimizu Bassi G, et al.
J Nat Prod
. 2016 Jul;
79(7):1828-33.
PMID: 27367493
Chemical compounds belonging to the class of coumarins have promising anti-inflammatory potential. Cinnamoyloxy-mammeisin (CNM) is a 4-phenylcoumarin that can be isolated from Brazilian geopropolis. To our knowledge, its anti-inflammatory activity...
9.
Vieira Pereira J, Freires I, Castilho A, da Cunha M, da Silva Alves H, Rosalen P
Pharm Biol
. 2016 Mar;
54(10):2312-9.
PMID: 26987037
Context The emergence of resistant pathogens and toxicity of antifungals have encouraged an active search for novel candidates to manage Candida biofilms. Objective In this study, the little known species...
10.
da Cunha M, Rosalen P, Franchin M, de Alencar S, Ikegaki M, Ransom T, et al.
Planta Med
. 2015 Nov;
82(3):190-4.
PMID: 26544117
Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type...