Marcello C Laurenti
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Explore the profile of Marcello C Laurenti including associated specialties, affiliations and a list of published articles.
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26
Citations
178
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Recent Articles
11.
Laurenti M, Arora P, Dalla Man C, Andrews J, Rizza R, Matveyenko A, et al.
Physiol Rep
. 2022 Jul;
10(13):e15380.
PMID: 35822422
Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship. However,...
12.
Adams J, Egan A, Laurenti M, Schembri Wismayer D, Bailey K, Cobelli C, et al.
Metab Syndr Relat Disord
. 2022 Apr;
20(6):329-335.
PMID: 35442800
The rs7903146 variant in the gene is associated with defects in postprandial insulin and glucagon secretion and increased risk of type 2 diabetes. However, it is unclear if this variant...
13.
Adams J, Egan A, Laurenti M, Schembri Wismayer D, Bailey K, Cobelli C, et al.
Am J Physiol Endocrinol Metab
. 2021 Oct;
321(5):E728-E736.
PMID: 34658253
Type 2 diabetes is a disease characterized by impaired insulin secretion and defective glucagon suppression in the postprandial period. We examined the effect of impaired glucagon suppression on glucose concentrations...
14.
Simha V, Lanza I, Dasari S, Klaus K, Le Brasseur N, Vuckovic I, et al.
J Clin Endocrinol Metab
. 2021 Oct;
107(2):346-362.
PMID: 34614176
Context: Familial partial lipodystrophy (FPL), Dunnigan variety is characterized by skeletal muscle hypertrophy and insulin resistance besides fat loss from the extremities. The cause for the muscle hypertrophy and its...
15.
Laurenti M, Matveyenko A, Vella A
Metabolites
. 2021 Jul;
11(7).
PMID: 34206296
Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with oscillatory pulses superimposed...
16.
Laurenti M, Dalla Man C, Varghese R, Andrews J, Jones J, Barosa C, et al.
J Clin Endocrinol Metab
. 2021 Feb;
106(6):1702-1709.
PMID: 33606017
Objective: Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are characterized by insulin resistance. This has led to the suggestion that changes in insulin pulsatility...
17.
Egan A, Laurenti M, Hurtado Andrade M, Dalla Man C, Cobelli C, Bailey K, et al.
Eur J Clin Invest
. 2020 Dec;
51(6):e13469.
PMID: 33289929
Background: The fasting proinsulin to insulin ratio is elevated in people with type 2 diabetes and has been suggested as a marker of β-cell health. However, its utility in discriminating...
18.
Laurenti M, Vella A, Adams J, Schembri Wismayer D, Egan A, Dalla Man C
Am J Physiol Endocrinol Metab
. 2020 Nov;
320(1):E71-E77.
PMID: 33135460
Impaired glucose tolerance arises out of impaired postprandial insulin secretion and delayed suppression of glucagon. These defects occur early and independently in the pathogenesis of prediabetes. Quantification of the contribution...
19.
Laurenti M, Dalla Man C, Varghese R, Andrews J, Rizza R, Matveyenko A, et al.
JCI Insight
. 2020 Mar;
5(7).
PMID: 32182220
BACKGROUNDMetabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously...
20.
Adams J, Dalla Man C, Laurenti M, Andrade M, Cobelli C, Rizza R, et al.
Metabolism
. 2020 Feb;
105:154175.
PMID: 32045582
Purpose: Abnormal glucagon concentrations are a feature of prediabetes but it is uncertain if α-cell dysfunction contributes to a longitudinal decline in β-cell function. We therefore sought to determine if...