Marcela Pavova
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Explore the profile of Marcela Pavova including associated specialties, affiliations and a list of published articles.
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8
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62
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Recent Articles
1.
Zackova S, Pavova M, Trylcova J, Chalupova J, Priss A, Luksan O, et al.
Cells
. 2024 May;
13(10.
PMID: 38786015
Adhesion G protein-coupled receptors (aGPCRs) play an important role in neurodevelopment, immune defence and cancer; however, their role throughout viral infections is mostly unexplored. We have been searching for specific...
2.
Pavova M, Reyes-Gutierrez P, Kozak J, Dobias J, Yurenko Y, Lepsik M, et al.
Sci Rep
. 2023 Apr;
13(1):6096.
PMID: 37055553
The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes. Several G-quadruplexes can be formed in the HIV-1 long...
3.
Simonova A, Svojanovska B, Trylcova J, Hubalek M, Moravcik O, Zavrel M, et al.
Sci Rep
. 2019 Jun;
9(1):8697.
PMID: 31213632
The mechanism of action of various viruses has been the primary focus of many studies. Yet, the data on RNA modifications in any type of virus are scarce. Methods for...
4.
Novotna E, Waisser K, Kunes J, Palat K, Skalova L, Szotakova B, et al.
Arch Pharm (Weinheim)
. 2017 Jun;
350(8).
PMID: 28635184
A series of benzaldehyde and salicylaldehyde-S-benzylisothiosemicarbazones was synthesized and tested against 12 different strains of mycobacteria, Gram-positive and Gram-negative bacteria, and the significant selectivity toward mycobacteria was proved. Twenty-eight derivatives...
5.
Weber J, Gibson R, Sacka L, Strunin D, Hodek J, Weberova J, et al.
AIDS Res Ther
. 2017 Mar;
14:15.
PMID: 28331526
Background: Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals-termed viremic non-progressors (VNP) or controllers-do not seem to progress...
6.
Kozisek M, Stepanek O, Parkan K, Albinana C, Pavova M, Weber J, et al.
Bioorg Med Chem Lett
. 2016 Jun;
26(15):3487-90.
PMID: 27353536
In an effort to identify an HIV-1 capsid assembly inhibitor with improved solubility and potency, we synthesized two series of pyrimidine analogues based on our earlier lead compound N-(4-(ethoxycarbonyl)phenyl)-2-(pyridine-4-yl)quinazoline-4-amine. In...
7.
Machara A, Lux V, Kozisek M, Grantz Saskova K, Stepanek O, Kotora M, et al.
J Med Chem
. 2015 Dec;
59(2):545-58.
PMID: 26685880
Assembly of human immunodeficiency virus (HIV-1) represents an attractive target for antiretroviral therapy which is not exploited by currently available drugs. We established high-throughput screening for assembly inhibitors based on...
8.
Schimer J, Pavova M, Anders M, Pachl P, Sacha P, Cigler P, et al.
Nat Commun
. 2015 Mar;
6:6461.
PMID: 25751579
HIV protease (PR) is required for proteolytic maturation in the late phase of HIV replication and represents a prime therapeutic target. The regulation and kinetics of viral polyprotein processing and...