Kamil Parkan
Overview
Explore the profile of Kamil Parkan including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
53
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Recent Articles
1.
Choutka J, Kaminsky J, Wang E, Parkan K, Pohl R
J Chem Inf Model
. 2025 Jan;
65(2):762-777.
PMID: 39754572
The use of quantum mechanical potentials in protein-ligand affinity prediction is becoming increasingly feasible with growing computational power. To move forward, validation of such potentials on real-world challenges is necessary....
2.
Prouza V, Zyka J, Kozak J, Magdolenova A, Pohl R, Parkan K
ChemMedChem
. 2024 Dec;
:e202400826.
PMID: 39673714
Galectins are a family of galactoside-binding proteins involved in various pathophysiological processes, which makes them attractive targets for drug discovery. The derivatization of d-galactose at C3 and C1 positions has...
3.
Zyka J, Prouza V, Habanova N, Pohl R, Parkan K
Carbohydr Res
. 2024 Jan;
536:109023.
PMID: 38242070
This paper describes a unified approach toward diglycosylamines using methanolic ammonia. All the glycosylamines prepared have been fully characterized, and their anomeric configuration has been determined. The article presents a...
4.
Choutka J, Parkan K, Pohl R, Kaminsky J
Carbohydr Res
. 2024 Jan;
535:109021.
PMID: 38171193
Aryl C-glycosides, in which the glycosidic bond is changed to a carbon-carbon bond, are an important family of biologically-active compounds. They often serve as secondary metabolites or exhibit antibiotic and...
5.
Kovalova A, Prouza V, Zavrel M, Hajek M, Dzijak R, Magdolenova A, et al.
Chempluschem
. 2023 Nov;
89(7):e202300567.
PMID: 37942669
Galectins, a class of carbohydrate-binding proteins, play a crucial role in various physiological and disease processes. Therefore, the identification of ligands that efficiently bind these proteins could potentially lead to...
6.
Choutka J, Kratochvil M, Cisarova I, Pohl R, Kaminsky J, Parkan K
Org Biomol Chem
. 2022 Jul;
20(38):7613-7621.
PMID: 35861668
Modification of the carbohydrate scaffold is an important theme in drug and vaccine discovery. Therefore, the preparation of novel types of glycomimetics is of interest in synthetic carbohydrate chemistry. In...
7.
Alonso-Gil S, Parkan K, Kaminsky J, Pohl R, Miyazaki T
Chemistry
. 2022 Jan;
28(14):e202200148.
PMID: 35049087
The conformational changes in a sugar moiety along the hydrolytic pathway are key to understand the mechanism of glycoside hydrolases (GHs) and to design new inhibitors. The two predominant itineraries...
8.
Vankova K, Rahm M, Choutka J, Pohl R, Parkan K
Chemistry
. 2021 Jun;
27(41):10488.
PMID: 34180093
Invited for the cover of this issue is Kamil Parkan and co-workers at University of Chemistry and Technology and Institute of Organic Chemistry and Biochemistry, Prague. The cover graphic depicts...
9.
Vankova K, Rahm M, Choutka J, Pohl R, Parkan K
Chemistry
. 2021 May;
27(41):10583-10588.
PMID: 34048112
Access to unprotected (hetero)aryl pseudo-C-glucosides via a mild Pd-catalysed Hiyama cross-coupling reaction of protecting-group-free 1-diisopropylsilyl-d-glucal with various (hetero)aryl halides has been developed. In addition, selected unprotected pseudo-C-glucosides were stereoselectively converted...
10.
Choutka J, Kratochvil M, Zyka J, Pohl R, Parkan K
Carbohydr Res
. 2020 Aug;
496:108086.
PMID: 32828008
A straightforward and scalable method for the synthesis of protected 2-hydroxyglycals is described. The approach is based on the chlorination of carbohydrate-derived hemiacetals, followed by an elimination reaction to establish...