Marcela Cristina Correa de Freitas
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Explore the profile of Marcela Cristina Correa de Freitas including associated specialties, affiliations and a list of published articles.
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9
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24
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Recent Articles
1.
Pedezzi R, de Biagi Junior C, de Freitas M, da Rosa-Garzon N, Cabral H
Braz J Microbiol
. 2021 Mar;
52(2):491-501.
PMID: 33651333
Filamentous fungus Purpureocillium lilacinum is an emerging pathogen that infects immunocompromised and immunocompetent individuals and is resistant to several azole molecules. Although azole resistance mechanisms are well studied in Aspergillus...
2.
Sousa Bomfim A, de Freitas M, Picanco Castro V, Abreu Soares Neto M, Padua R, Covas D, et al.
Biotechnol Lett
. 2020 Nov;
43(1):143-152.
PMID: 33130980
Objective: To develop recombinant factor IX (FIX) variants with augmented clotting activity. Results: We generated three new variants, FIX-YKALW, FIX-ALL and FIX-LLW, expressed in SK-Hep-1 cells and characterized in vitro...
3.
de Sousa Bomfim A, de Freitas M, Covas D, de Sousa Russo E
Methods Mol Biol
. 2017 Sep;
1674:49-61.
PMID: 28921427
The gamma-carboxylated proteins belong to a family of proteins that depend on vitamin K for normal biosynthesis. The major representative gamma-carboxylated proteins are the coagulation system proteins, for example, factor...
4.
de Freitas M, de Sousa Bomfim A, Mizukami A, Picanco-Castro V, Swiech K, Covas D
Protein Expr Purif
. 2017 Jun;
137:26-33.
PMID: 28651975
Recombinant factor VII (rFVII) is the main therapeutic choice for hemophilia patients who have developed inhibitory antibodies against conventional treatments (FVIII and FIX). Because of the post-translational modifications, rFVII needs...
5.
de Sousa Bomfim A, de Freitas M, Picanco-Castro V, de Abreu Soares Neto M, Swiech K, Covas D, et al.
Protein Expr Purif
. 2016 Jan;
121:149-56.
PMID: 26802680
Factor IX (FIX) is a vitamin K-dependent protein, and it has become a valuable pharmaceutical in the Hemophilia B treatment. We evaluated the potential of recombinant human FIX (rhFIX) expression...
6.
Castilho-Fernandes A, Maria Fontes A, Abraham K, de Freitas M, Gonsales da Rosa N, Picanco-Castro V, et al.
Biotechnol Lett
. 2015 Feb;
37(5):991-1001.
PMID: 25650340
Ligation-mediated-PCR was performed followed by the mapping of 177 and 150 integration sites from HepG2 and Hek293 transduced with chimera vector carrying recombinant human Factor IX (rhFIX) cDNA, respectively. The...
7.
Swiech K, de Freitas M, Covas D, Picanco-Castro V
Methods Mol Biol
. 2014 Dec;
1258:223-40.
PMID: 25447867
The most important properties of a protein are determined by its primary structure, its amino acid sequence. However, protein features can be also modified by a large number of posttranslational...
8.
Picanco-Castro V, de Freitas M, de Sousa Bomfim A, de Sousa Russo E
Recent Pat Biotechnol
. 2014 Sep;
8(2):165-71.
PMID: 25185983
The industrial production of recombinant proteins preferentially requires the generation of stable cell lines expressing proteins in a quick, relatively facile, and a reproducible manner. Different methods are used to...
9.
de Freitas M, Maria Fontes A, de Castilho Fernandes A, Picanco-Castro V, de Sousa Russo E, Covas D
Rev Bras Hematol Hemoter
. 2014 Jul;
36(3):213-8.
PMID: 25031062
Objective: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO) and baby hamster kidney cells (BHK). Previous studies, using the murine leukemia virus-derived retroviral...