Marc R Wilkins
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Explore the profile of Marc R Wilkins including associated specialties, affiliations and a list of published articles.
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Articles
181
Citations
3159
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Recent Articles
1.
Coppens S, Deconinck N, Sullivan P, Smolnikov A, Clayton J, Griffin K, et al.
Ann Neurol
. 2025 Jan;
97(4):611-628.
PMID: 39853809
Objective: To better understand the presentation and clinical needs of the under-characterized extreme end of the congenital titinopathy severity spectrum. Methods: We comprehensively analyzed the clinical, imaging, pathology, autopsy, and...
2.
Cheng Y, Jones J, Yu T, Olzomer E, Su J, Katen A, et al.
Bioorg Chem
. 2024 Aug;
151:107725.
PMID: 39164138
No abstract available.
3.
Cheng Y, Jones J, Yu T, Olzomer E, Su J, Katen A, et al.
Bioorg Chem
. 2024 Aug;
151:107665.
PMID: 39094508
Compared to normal cells, tumour cells exhibit an upregulation of glucose transporters and an increased rate of glycolytic activity. In previous research, we successfully identified a promising hit compound BH10...
4.
Hogg C, Edwards R, Farquharson K, Silver L, Brandies P, Peel E, et al.
Nat Ecol Evol
. 2024 Jul;
8(9):1776.
PMID: 39075174
No abstract available.
5.
Hogg C, Edwards R, Farquharson K, Silver L, Brandies P, Peel E, et al.
Nat Ecol Evol
. 2024 Jun;
8(7):1311-1326.
PMID: 38945974
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers and conservation managers, we generated the Ninu chromosome-level genome assembly (3.66 Gbp) and...
6.
Separovich R, Karakatsanis N, Gao K, Fuh D, Hamey J, Wilkins M
FEBS J
. 2024 Jan;
291(12):2590-2614.
PMID: 38270553
Disruptor of telomeric silencing 1 (Dot1p) is an exquisitely conserved histone methyltransferase and is the sole enzyme responsible for H3K79 methylation in the budding yeast Saccharomyces cerevisiae. It has been...
7.
Karakatsanis N, Hamey J, Wilkins M
Trends Biochem Sci
. 2024 Jan;
49(3):257-276.
PMID: 38233282
Histone lysine demethylases (KDMs) regulate eukaryotic gene transcription by catalysing the removal of methyl groups from histone proteins. These enzymes are intricately regulated by the kinase signalling system in response...
8.
Hamey J, Nguyen A, Haddad M, Vazquez-Campos X, Pfeiffer P, Wilkins M
J Biol Chem
. 2024 Jan;
300(2):105639.
PMID: 38199565
Translation elongation factor 1A (eEF1A) is an essential and highly conserved protein required for protein synthesis in eukaryotes. In both Saccharomyces cerevisiae and human, five different methyltransferases methylate specific residues...
9.
Kopecky C, Haug M, Reischl B, Deshpande N, Manandhar B, King T, et al.
J Cachexia Sarcopenia Muscle
. 2023 Dec;
15(1):112-123.
PMID: 38124345
Background: Decreased insulin availability and high blood glucose levels, the hallmark features of poorly controlled diabetes, drive disease progression and are associated with decreased skeletal muscle mass. We have shown...
10.
Manandhar B, Pandzic E, Deshpande N, Chen S, Wasinger V, Kockx M, et al.
Arterioscler Thromb Vasc Biol
. 2023 Dec;
44(2):e20-e38.
PMID: 38095105
Background: High cholesterol levels in pancreatic β-cells cause oxidative stress and decrease insulin secretion. β-cells can internalize apo (apolipoprotein) A-I, which increases insulin secretion. This study asks whether internalization of...