Marc R Bornstein
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Explore the profile of Marc R Bornstein including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
257
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Recent Articles
1.
Axsom J, TeSlaa T, Lee W, Chu Q, Cowan A, Bornstein M, et al.
Cell Metab
. 2024 Oct;
36(12):2560-2579.e5.
PMID: 39413791
Despite the known metabolic benefits of exercise, an integrated metabolic understanding of exercise is lacking. Here, we use in vivo steady-state isotope-labeled infusions to quantify fuel flux and oxidation during...
2.
Bornstein M, Tian R, Arany Z
Cell Metab
. 2024 Jul;
36(7):1456-1481.
PMID: 38959861
The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models....
3.
Bornstein M, Neinast M, Zeng X, Chu Q, Axsom J, Thorsheim C, et al.
Cell Metab
. 2023 Oct;
35(11):2077-2092.e6.
PMID: 37802078
Cold-induced thermogenesis (CIT) is widely studied as a potential avenue to treat obesity, but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we present a comprehensive...
4.
Blair M, Neinast M, Jang C, Chu Q, Jung J, Axsom J, et al.
Nat Metab
. 2023 Apr;
5(4):589-606.
PMID: 37100997
Elevated levels of plasma branched-chain amino acids (BCAAs) have been associated with insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of branched-chain α-ketoacid dehydrogenase (BCKDH), the rate-limiting...
5.
Vanweert F, Neinast M, Tapia E, van de Weijer T, Hoeks J, Schrauwen-Hinderling V, et al.
Nat Commun
. 2022 Jun;
13(1):3508.
PMID: 35717342
Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels improve glucose tolerance, but data in...
6.
Gosis B, Wada S, Thorsheim C, Li K, Jung S, Rhoades J, et al.
Science
. 2022 Apr;
376(6590):eabf8271.
PMID: 35420934
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) pathway is a potential therapeutic target, but conflicting interpretations...
7.
Insulin-stimulated adipocytes secrete lactate to promote endothelial fatty acid uptake and transport
Ibrahim A, Neinast M, Li K, Noji M, Kim B, Bornstein M, et al.
J Cell Sci
. 2021 Nov;
135(5).
PMID: 34779480
Insulin stimulates adipose tissue to extract fatty acids from circulation and sequester them inside adipose cells. How fatty acids are transported across the capillary endothelial barrier, and how this process...
8.
Luongo T, Eller J, Lu M, Niere M, Raith F, Perry C, et al.
Nature
. 2020 Sep;
588(7836):174-179.
PMID: 32906142
Mitochondria require nicotinamide adenine dinucleotide (NAD) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD transporters have been identified in yeast and plants,...
9.
Hostetler Z, Ferrie J, Bornstein M, Sungwienwong I, Petersson E, Kohli R
ACS Chem Biol
. 2018 Sep;
13(10):2855-2861.
PMID: 30216041
Improvements in genetic code expansion have made preparing proteins with diverse functional groups almost routine. Nonetheless, unnatural amino acids (Uaas) pose theoretical burdens on protein solubility, and determinants of position-specific...