Manuela Kuchar
Overview
Explore the profile of Manuela Kuchar including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
118
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0
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Recent Articles
1.
Loser R, Kuchar M, Wodtke R, Neuber C, Belter B, Kopka K, et al.
ChemMedChem
. 2023 Aug;
18(18):e202300331.
PMID: 37565736
The understanding of the contribution of the tumour microenvironment to cancer progression and metastasis, in particular the interplay between tumour cells, fibroblasts and the extracellular matrix has grown tremendously over...
2.
Kniess T, Zessin J, Mading P, Kuchar M, Kiss O, Kopka K
EJNMMI Radiopharm Chem
. 2023 Mar;
8(1):5.
PMID: 36897480
Background: [F]fluoromisonidazole ([F]FMISO, 1H-1-(3-[F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells. Since hypoxia is prevalent in solid tumors, [F]FMISO is in clinical application for decades to...
3.
Loser R, Bader M, Kuchar M, Wodtke R, Lenk J, Wodtke J, et al.
Amino Acids
. 2018 Sep;
51(2):219-244.
PMID: 30264172
The cell surface receptor claudin-4 (Cld-4) is upregulated in various tumours and represents an important emerging target for both diagnosis and treatment of solid tumours of epithelial origin. The C-terminal...
4.
Kuchar M, Neuber C, Belter B, Bergmann R, Lenk J, Wodtke R, et al.
Front Chem
. 2018 May;
6:121.
PMID: 29755969
Accumulating evidence suggests an unequivocal role of lysyl oxidases as key players of tumor progression and metastasis, which renders this enzyme family highly attractive for targeted non-invasive functional imaging of...
5.
Kuchar M, Mamat C
Molecules
. 2015 Sep;
20(9):16186-220.
PMID: 26404227
The majority of pharmaceuticals and other organic compounds incorporating radiotracers that are considered foreign to the body undergo metabolic changes in vivo. Metabolic degradation of these drugs is commonly caused...
6.
Wuest M, Kuchar M, Sharma S, Richter S, Hamann I, Wang M, et al.
Breast Cancer Res
. 2015 Aug;
17:107.
PMID: 26265048
Introduction: Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1-LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX...
7.
Wodtke R, Ruiz-Gomez G, Kuchar M, Pisabarro M, Novotna P, Urbanova M, et al.
Org Biomol Chem
. 2014 Dec;
13(6):1878-96.
PMID: 25503999
The collagen telopeptides play an important role for lysyl oxidase-mediated crosslinking, a process which is deregulated during tumour progression. The DEKS motif which is located within the N-terminal telopeptide of...
8.
Loser R, Bergmann R, Frizler M, Mosch B, Dombrowski L, Kuchar M, et al.
ChemMedChem
. 2013 Jun;
8(8):1330-44.
PMID: 23785011
A fluorinated cathepsin inhibitor based on the azadipeptide nitrile chemotype was prepared and selected for positron emission tomography (PET) tracer development owing to its high affinity for the oncologically relevant...
9.
Pretze M, Kuchar M, Bergmann R, Steinbach J, Pietzsch J, Mamat C
ChemMedChem
. 2013 Apr;
8(6):935-45.
PMID: 23559494
The EphB2 receptor is known to be overexpressed in various types of cancer and is therefore a promising target for tumor cell imaging by positron emission tomography (PET). In this...
10.
Kuchar M, Oliveira M, Gano L, Santos I, Kniess T
Bioorg Med Chem Lett
. 2012 Mar;
22(8):2850-5.
PMID: 22444679
Sunitinib® (SU11248) is a highly potent tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR). Radiolabeled inhibitors of RTKs might be useful tools for monitoring RTKs levels in tumour...