Manuel J Lopez-Perez
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Explore the profile of Manuel J Lopez-Perez including associated specialties, affiliations and a list of published articles.
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594
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Recent Articles
1.
Monge-Ochoa B, Montoro L, Montoya J, Ruiz-Pesini E, Lopez-Perez M, de Castro F, et al.
J Assist Reprod Genet
. 2023 Jan;
40(3):671-682.
PMID: 36701026
Purpose: To analyze the influence of Caucasian mitochondrial haplogroups on controlled ovarian stimulation outcome (COS), embryo (E), and pregnancy success. Methods: In a Caucasian population (n = 517) undergoing COS,...
2.
Monge-Ochoa B, Montoro L, Gil-Arribas E, Montoya J, Ruiz-Pesini E, Lopez-Perez M, et al.
J Assist Reprod Genet
. 2021 Aug;
38(10):2769-2779.
PMID: 34346002
Purpose: To determine the influence of different genotypes of Ala307Thr and Asn680Ser FSHr polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy. Methods: This study collected blood and physiological and...
3.
Emperador S, Pacheu-Grau D, Bayona-Bafaluy M, Garrido-Perez N, Martin-Navarro A, Lopez-Perez M, et al.
Front Genet
. 2015 Feb;
5:469.
PMID: 25642242
Several homoplasmic pathologic mutations in mitochondrial DNA, such as those causing Leber hereditary optic neuropathy or non-syndromic hearing loss, show incomplete penetrance. Therefore, other elements must modify their pathogenicity. Discovery...
4.
Gomez-Duran A, Pacheu-Grau D, Martinez-Romero I, Lopez-Gallardo E, Lopez-Perez M, Montoya J, et al.
Biochim Biophys Acta
. 2012 May;
1822(8):1216-22.
PMID: 22561905
Leber's hereditary optic neuropathy is a maternally inherited optic atrophy caused by mitochondrial DNA point mutations. Previous epidemiological studies have shown that individuals from mitochondrial genetic backgrounds (haplogroups) J/Uk and...
5.
Pacheu-Grau D, Gomez-Duran A, Lopez-Gallardo E, Pinos T, Andreu A, Lopez-Perez M, et al.
Hum Mol Genet
. 2011 Aug;
20(21):4224-31.
PMID: 21828074
A human mitochondrial DNA (mtDNA) transition, m.1555A>G, in the 12S rRNA gene causes non-syndromic hearing loss. However, this pathological mutation is the wild-type allele in orangutan mtDNA. Here we rule...
6.
Gomez-Duran A, Pacheu-Grau D, Lopez-Perez M, Montoya J, Ruiz-Pesini E
Drug Discov Today
. 2010 Nov;
16(5-6):176-80.
PMID: 21112412
Genetic variation in human cytochrome b generates structurally different coenzyme Q binding pockets, affects the coupling efficiency of the oxidative phosphorylation system and susceptibility to different medical conditions. As modification...
7.
Gomez-Duran A, Pacheu-Grau D, Lopez-Gallardo E, Diez-Sanchez C, Montoya J, Lopez-Perez M, et al.
Hum Mol Genet
. 2010 Jun;
19(17):3343-53.
PMID: 20566709
Many epidemiologic studies have associated human mitochondrial haplogroups to rare mitochondrial diseases like Leber's hereditary optic neuropathy or to more common age-linked disorders such as Parkinson's disease. However, cellular, biochemical...
8.
Montoya J, Lopez-Gallardo E, Herrero-Martin M, Martinez-Romero I, Gomez-Duran A, Pacheu D, et al.
Adv Exp Med Biol
. 2010 Mar;
652:47-67.
PMID: 20225019
Mitochondrial diseases, or diseases of the oxidative phosphorylation system, consist of a group of disorders originated by a deficient synthesis of ATP. This system is composed of proteins codified in...
9.
Martinez-Redondo D, Marcuello A, Casajus J, Ara I, Dahmani Y, Montoya J, et al.
Mitochondrion
. 2009 Nov;
10(2):102-7.
PMID: 19900587
Mitochondrial background has been demonstrated to influence maximal oxygen uptake (VO(2max), in mLkg(-1)min(-1)), but this genetic influence can be compensated for by regular exercise. A positive correlation among electron transport...
10.
Pacheu-Grau D, Gomez-Duran A, Lopez-Perez M, Montoya J, Ruiz-Pesini E
Drug Discov Today
. 2009 Nov;
15(1-2):33-9.
PMID: 19883791
Ribosomal RNA (rRNA)-targeting drugs inhibit protein synthesis and represent effective antibiotics for the treatment of infectious diseases. Given the bacterial origins of mitochondria, the molecular and structural components of the...