Manu Shivakumar
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Explore the profile of Manu Shivakumar including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
367
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Recent Articles
1.
Jung S, Kim H, Jung Y, Shivakumar M, Xiao B, Kim J, et al.
Nat Commun
. 2025 Feb;
16(1):1463.
PMID: 39920105
The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have...
2.
Shivakumar M, Kim Y, Jung S, Woerner J, Kim D
Pac Symp Biocomput
. 2024 Dec;
30:551-564.
PMID: 39670395
The incidence of chronic kidney disease (CKD) is increasing worldwide, but there is no specific treatment available. Therefore, understanding and controlling the risk factors for CKD are essential for preventing...
3.
Woerner J, Westbrook T, Jeong S, Shivakumar M, Greenplate A, Apostolidis S, et al.
Pac Symp Biocomput
. 2024 Dec;
30:522-534.
PMID: 39670393
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), has a significant genetic component and is increasingly prevalent due to environmental factors. Current polygenic risk scores (PRS)...
4.
Abramowitz S, Boulier K, Keat K, Cardone K, Shivakumar M, DePaolo J, et al.
JAMA
. 2024 Nov;
333(1):60-70.
PMID: 39549270
Importance: Polygenic risk scores (PRSs) for coronary heart disease (CHD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease susceptibility remains incompletely characterized....
5.
Abramowitz S, Boulier K, Keat K, Cardone K, Shivakumar M, DePaolo J, et al.
medRxiv
. 2024 Aug;
PMID: 39108513
Importance: Polygenic risk scores (PRSs) for coronary artery disease (CAD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease liability is a critical...
6.
Mu S, Bao J, Xu H, Shivakumar M, Yang S, Ning X, et al.
AMIA Jt Summits Transl Sci Proc
. 2024 Jun;
2024:344-353.
PMID: 38827096
Neurodegenerative processes are increasingly recognized as potential causative factors in Alzheimer's disease (AD) pathogenesis. While many studies have leveraged mediation analysis models to elucidate the underlying mechanisms linking genetic variants...
7.
Nam Y, Kim J, Jung S, Woerner J, Suh E, Lee D, et al.
Annu Rev Biomed Data Sci
. 2024 May;
7(1):225-250.
PMID: 38768397
The integration of multiomics data with detailed phenotypic insights from electronic health records marks a paradigm shift in biomedical research, offering unparalleled holistic views into health and disease pathways. This...
8.
Leiby J, Lee M, Shivakumar M, Choe E, Kim D
J Transl Med
. 2024 May;
22(1):434.
PMID: 38720370
Background: Cardiometabolic disorders pose significant health risks globally. Metabolic syndrome, characterized by a cluster of potentially reversible metabolic abnormalities, is a known risk factor for these disorders. Early detection and...
9.
Jung S, Lee Y, Shivakumar M, Kim J, Yun J, Park W, et al.
BMC Med
. 2024 Mar;
22(1):141.
PMID: 38532472
Background: Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among...
10.
Lee Y, Jung S, Shivakumar M, Cha S, Park W, Won H, et al.
BMC Med
. 2024 Mar;
22(1):120.
PMID: 38486201
Background: Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design limitations...