Manu Anantpadma
Overview
Explore the profile of Manu Anantpadma including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
887
Followers
0
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Recent Articles
1.
Sacramento C, Bott R, Huang Q, Eaton B, Postnikova E, Sabir A, et al.
Antiviral Res
. 2025 Feb;
236:106117.
PMID: 39970958
Several arenaviruses, such as the Old World (OW) Lassa virus (LASV) and the New World (NW) Junin virus (JUNV), can cause severe and lethal viral hemorrhagic fevers in humans. Currently,...
2.
Bu F, Ye G, Morsheimer K, Mendoza A, Turner-Hubbard H, Herbst M, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012817.
PMID: 39715280
The Ebola filovirus (EBOV) poses a serious threat to global health and national security. Nanobodies, a type of single-domain antibody, have demonstrated promising therapeutic potential. We identified two anti-EBOV nanobodies,...
3.
Argade M, Achi J, Bott R, Morsheimer K, Owen C, Zielinski C, et al.
J Med Chem
. 2024 Dec;
68(1):135-155.
PMID: 39680623
Ebola and Marburg (EBOV and MARV) filoviral infections lead to fatal hemorrhagic fevers and have caused over 30 outbreaks in the last 50 years. Currently, there are no FDA-approved small...
4.
Wang L, Estrada L, Wiggins J, Anantpadma M, Patten J, Davey R, et al.
Antiviral Res
. 2022 Aug;
206:105399.
PMID: 36007601
Filoviruses enter cells through macropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm. The...
5.
Patten J, Keiser P, Morselli-Gysi D, Menichetti G, Mori H, Donahue C, et al.
iScience
. 2022 Aug;
25(9):104925.
PMID: 35992305
Pharmacologically active compounds with known biological targets were evaluated for inhibition of SARS-CoV-2 infection in cell and tissue models to help identify potent classes of active small molecules and to...
6.
Plescia C, Lindstrom A, Quintero M, Keiser P, Anantpadma M, Davey R, et al.
ACS Infect Dis
. 2022 Mar;
8(5):942-957.
PMID: 35357134
Ebola virus (EBOV) is an aggressive filoviral pathogen that can induce severe hemorrhagic fever in humans with up to 90% fatality rate. To date, there are no clinically effective small-molecule...
7.
Batra J, Mori H, Small G, Anantpadma M, Shtanko O, Mishra N, et al.
EMBO J
. 2021 Jul;
40(18):e105658.
PMID: 34260076
The Ebola virus VP30 protein interacts with the viral nucleoprotein and with host protein RBBP6 via PPxPxY motifs that adopt non-canonical orientations, as compared to other proline-rich motifs. An affinity...
8.
Patten J, Keiser P, Gysi D, Menichetti G, Mori H, Donahue C, et al.
bioRxiv
. 2021 Apr;
PMID: 33907750
Identification of host factors contributing to replication of viruses and resulting disease progression remains a promising approach for development of new therapeutics. Here, we evaluated 6710 clinical and preclinical compounds...
9.
Wang L, Palermo N, Estrada L, Thompson C, Patten J, Anantpadma M, et al.
Antiviral Res
. 2021 Mar;
189:105059.
PMID: 33705865
Filoviruses, mainly consisting of Ebola viruses (EBOV) and Marburg viruses (MARV), are enveloped negative-strand RNA viruses which can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality...
10.
Keiser P, Anantpadma M, Staples H, Carrion R, Davey R
Microorganisms
. 2021 Jan;
9(1).
PMID: 33445537
Ongoing efforts to develop effective therapies against filoviruses rely, to different extents, on quantifying the amount of viable virus in samples by plaque, TCID, and focus assays. Unfortunately, these techniques...