Manolis C Demetriou
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Explore the profile of Manolis C Demetriou including associated specialties, affiliations and a list of published articles.
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9
Citations
164
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Recent Articles
1.
Demetriou M, Kwei K, Powell M, Nagle R, Bowden G, Cress A
Open Cancer J
. 2010 Jul;
2:1-4.
PMID: 20664806
We have previously identified a structural variant of the α6 integrin (Laminin receptor) called α6p. The α6p variant is a 70 kDa form of the full-length α6 integrin (140 kDa)...
2.
King T, Pawar S, Majuta L, Sroka I, Wynn D, Demetriou M, et al.
PLoS One
. 2008 Oct;
3(10):e3535.
PMID: 18958175
Of the estimated 565,650 people in the U.S. who will die of cancer in 2008, almost all will have metastasis. Breast, prostate, kidney, thyroid and lung cancers metastasize to the...
3.
Demetriou M, Stylianou P, Andreou M, Yiannikouri O, Tsaprailis G, Cress A, et al.
Biochem Biophys Res Commun
. 2007 Dec;
366(3):779-85.
PMID: 18083114
The alpha6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin alpha6 (alpha6p), in invasive human prostate cancer...
4.
Pawar S, Dougherty S, Pennington M, Demetriou M, Stea B, Dorr R, et al.
Int J Radiat Biol
. 2007 Dec;
83(11-12):761-7.
PMID: 18058365
Purpose: The goal was to determine if prostate tumor cells containing a mutant alpha6 integrin would be defective in tumor re-population following clinically relevant fractionated ionizing radiation (IR) treatments. Material...
5.
Pawar S, Demetriou M, Nagle R, Bowden G, Cress A
Exp Cell Res
. 2007 Feb;
313(6):1080-9.
PMID: 17303120
Integrins play a major role in cell adhesion and migration. Previous work reported that a cleaved form of integrin alpha6 (alpha6p) was detected in invasive human prostate cancer tissue, absent...
6.
Demetriou M, Pennington M, Nagle R, Cress A
Exp Cell Res
. 2004 Mar;
294(2):550-8.
PMID: 15023541
During human prostate cancer progression, the integrin alpha6beta1 (laminin receptor) is expressed on the cancer cell surface during invasion and in lymph node metastases. We previously identified a novel structural...
7.
Demetriou M, Cress A
J Cell Biochem
. 2003 Dec;
91(1):26-35.
PMID: 14689578
During human prostate cancer progression, the majority of normally expressed integrins are suppressed with the exception of the alpha6, alpha3, and beta1 integrins. We have shown that in prostate cancer,...
8.
Chauhan S, Kunz S, Davis K, Roberts J, Martin G, Demetriou M, et al.
J Biol Chem
. 2003 Oct;
279(2):937-44.
PMID: 14576147
We recently generated an HT-1080-derived cell line called HT-AR1 that responds to dihydrotestosterone (DHT) treatment by undergoing cell growth arrest in association with cytoskeletal reorganization and induction of neuroendocrine-like cell...
9.
Chauhan S, Pandey R, Way J, Sroka T, Demetriou M, Kunz S, et al.
Biochem Biophys Res Commun
. 2003 Oct;
310(2):421-32.
PMID: 14521927
We have developed a cell model to investigate steroid control of differentiation using a subline of HT1080 cells (HT-AR1) that have been engineered to express the human androgen receptor. Dihydrotestosterone...