Manjiong Wang
Overview
Explore the profile of Manjiong Wang including associated specialties, affiliations and a list of published articles.
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16
Citations
94
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Recent Articles
1.
Liu H, Guo X, Yang J, Xia C, Yao Y, Li X, et al.
J Med Chem
. 2025 Feb;
68(4):4540-4560.
PMID: 39925333
Heart failure (HF) is a major global health threat, characterized by high morbidity and mortality. Targeting cardiac hypertrophy has been identified as a potential therapy for HF, with current treatments...
2.
Song J, Li R, Huang Z, Qian Y, Wang X, Shao Q, et al.
Bioorg Med Chem
. 2024 Nov;
115:117985.
PMID: 39509760
In previous studies, we identified the clinical antitumor drug candidate Quisinostat is a potent Plasmodium falciparum histone deacetylase (PfHDAC) inhibitor with significant activity against drug-resistant malaria but with severe toxicity....
3.
Huang Y, Chen X, Yang J, Yao Y, Wang M, Lu T, et al.
J Chem Inf Model
. 2024 Sep;
64(18):7152-7162.
PMID: 39259971
Combination therapy is increasingly favored by pharmaceutical companies and researchers as an effective way to quickly discover new drugs with excellent efficacy, especially in the treatment of complex diseases. Previously,...
4.
Xia C, Wang M, Guan Y, Li J
Front Genet
. 2022 Jun;
13:878182.
PMID: 35711937
is an important medicinal group of the Ranunculaceae family and has been used as conventional medicine in Bai, Yi, and other ethnic groups of China. There are about 350 species...
5.
Xia C, Wang M, Guan Y, Li Y, Li J
Sci Rep
. 2022 Jun;
12(1):9439.
PMID: 35676401
Aconitum episcopale Leveille is an important medicinal plant from the genus Aconitum L. of Ranunculaceae family and has been used as conventional medicine in Bai, Yi, and other ethnic groups...
6.
Wang M, Tang T, Li R, Huang Z, Ling D, Zheng L, et al.
J Med Chem
. 2022 Feb;
65(5):4156-4181.
PMID: 35175762
Our previous work found that the clinical histone deacetylase (HDAC) inhibitor quisinostat exhibited a significant antimalarial effect but with severe toxicity. In this work, 35 novel derivatives were designed and...
7.
Huang Y, Wang J, Liu J, Shi D, Li X, Wang M, et al.
J Chem Inf Model
. 2021 Jun;
62(21):5223-5232.
PMID: 34151561
Combination drugs, characterized by high efficacy and few side effects, have received extensive attention from pharmaceutical companies and researchers for the treatment of complex diseases such as heart failure (HF)....
8.
Li R, Ling D, Tang T, Huang Z, Wang M, Ding Y, et al.
J Med Chem
. 2021 Feb;
64(4):2254-2271.
PMID: 33541085
Previously, we identified the clinical anticancer drug candidate quisinostat as a novel and potent antimalarial lead compound. To further enhance the antimalarial effect and improve safety, 31 novel spirocyclic hydroxamic...
9.
Huang Z, Li R, Tang T, Ling D, Wang M, Xu D, et al.
Cell Discov
. 2020 Dec;
6(1):93.
PMID: 33311461
Although artemisinin combination therapies have succeeded in reducing the global burden of malaria, multidrug resistance of the deadliest malaria parasite, Plasmodium falciparum, is emerging worldwide. Innovative antimalarial drugs that kill...
10.
Peng Y, Wang M, Xu Y, Wu Z, Wang J, Zhang C, et al.
Brief Bioinform
. 2020 Mar;
22(2):2058-2072.
PMID: 32221552
Drug discovery and development is a time-consuming and costly process. Therefore, drug repositioning has become an effective approach to address the issues by identifying new therapeutic or pharmacological actions for...