Manisha Brahmachary
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Explore the profile of Manisha Brahmachary including associated specialties, affiliations and a list of published articles.
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20
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1590
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Recent Articles
1.
Serna L, Azcoaga P, Brahmachary M, Caffarel M, Braza M
Front Immunol
. 2023 May;
14:1048567.
PMID: 37205092
Inflammasomes are cytosolic signaling hubs that promote the inflammatory response (i.e. an immune reaction to counteract threats in physiological conditions). Their potential role in lymphomagenesis remains to be elucidated. Depending...
2.
Li Y, Amaladas N, OMahony M, Manro J, Inigo I, Li Q, et al.
PLoS One
. 2022 Jul;
17(7):e0268244.
PMID: 35849586
Prolonged activation of vascular endothelial growth factor receptor-2 (VEGFR-2) due to mis-regulation of the VEGF pathway induces aberrant blood vessel expansion, which supports growth and survival of solid tumors. Therapeutic...
3.
Lozano-Ojalvo D, Camara C, Lopez-Granados E, Nozal P, Del Pino-Molina L, Bravo-Gallego L, et al.
Cell Rep
. 2021 Aug;
36(8):109570.
PMID: 34390647
The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals....
4.
Autio K, Klebanoff C, Schaer D, Kauh J, Slovin S, Adamow M, et al.
Clin Cancer Res
. 2020 Aug;
26(21):5609-5620.
PMID: 32847933
Purpose: Tumor-associated macrophages correlate with increased invasiveness, growth, and immunosuppression. Activation of the colony-stimulating factor-1 receptor (CSF-1R) results in proliferation, differentiation, and migration of monocytes/macrophages. This phase I study evaluated...
5.
Dumbuya H, Grimes P, Lynch S, Ji K, Brahmachary M, Zheng Q, et al.
J Drugs Dermatol
. 2020 Jul;
19(7):712-717.
PMID: 32726103
Visible light (400-700nm), which contributes to 45% of solar radiation, contributes to skin darkening and worsening of dyschromias, particularly in individuals with Fitzpatrick skin phototypes III and higher. Currently, sunscreens...
6.
Litchfield L, Boehnke K, Brahmachary M, Mur C, Bi C, Stephens J, et al.
Oncotarget
. 2020 May;
11(17):1478-1492.
PMID: 32391118
Aberrant activation of mitogenic signaling pathways in cancer promotes growth and proliferation of cells by activating mTOR and S6 phosphorylation, and D-cyclin kinases and Rb phosphorylation, respectively. Correspondingly, inhibition of...
7.
Hurvitz S, Martin M, Press M, Chan D, Fernandez-Abad M, Petru E, et al.
Clin Cancer Res
. 2019 Oct;
26(3):566-580.
PMID: 31615937
Purpose: neoMONARCH assessed the biological effects of abemaciclib in combination with anastrozole in the neoadjuvant setting. Patients And Methods: Postmenopausal women with stage I-IIIB HR/HER2 breast cancer were randomized to...
8.
Schaer D, Geeganage S, Amaladas N, Lu Z, Rasmussen E, Sonyi A, et al.
Clin Cancer Res
. 2019 Aug;
25(23):7175-7188.
PMID: 31409612
Purpose: Combination strategies leveraging chemotherapeutic agents and immunotherapy have held the promise as a method to improve benefit for patients with cancer. However, most chemotherapies have detrimental effects on immune...
9.
Braza M, van Leent M, Lameijer M, Sanchez-Gaytan B, Arts R, Perez-Medina C, et al.
Immunity
. 2018 Nov;
49(5):819-828.e6.
PMID: 30413362
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation mouse model, we demonstrate that local macrophage activation through dectin-1 and toll-like receptor...
10.
Braza M, Conde P, Garcia M, Cortegano I, Brahmachary M, Pothula V, et al.
Am J Transplant
. 2018 Jan;
18(5):1247-1255.
PMID: 29314558
The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to...