Manikandan Selvaraju
Overview
Explore the profile of Manikandan Selvaraju including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
31
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Recent Articles
1.
Tang Z, Hegde S, Hao S, Selvaraju M, Qiu J, Wang J
Nat Commun
. 2025 Jan;
16(1):483.
PMID: 39779694
One of the hallmarks of RNA viruses is highly structured untranslated regions (UTRs) which are often essential for viral replication, transcription, or translation. In this report, we discovered a series...
2.
Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, et al.
ACS Med Chem Lett
. 2024 May;
15(5):653-658.
PMID: 38746895
Previously we identified a non-nucleotide agonist BDW568 that selectively activates the human STING allele. Here, we further characterized the mechanism of BDW568 and highlighted its potential use for selectively controlling...
3.
Intelli A, Pal M, Selvaraju M, Altman R
Synthesis (Stuttg)
. 2023 Nov;
55(21):3568-3574.
PMID: 37915377
A Pd-catalyzed decarboxylative dearomatization reaction of a heterocyclic substrate enables access to an uncommon reaction intermediate that rearomatizes in the presence of amine bases in a net C-H functionalization sequence....
4.
Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, et al.
bioRxiv
. 2023 Jul;
PMID: 37425806
Previously we identified a non-nucleotide tricyclic agonist BDW568 that activates human STING (stimulator of interferon genes) gene variant containing A230 in a human monocyte cell line (THP-1). STING alleles, including...
5.
Tang Z, Hegde S, Hao S, Selvaraju M, Qiu J, Wang J
bioRxiv
. 2023 Apr;
PMID: 37066172
One of the hallmarks of RNA viruses is highly structured untranslated regions (UTRs) in their genomes. These conserved RNA structures are often essential for viral replication, transcription, or translation. In...
6.
Zhao J, Tang Z, Selvaraju M, Johnson K, Douglas J, Gao P, et al.
ACS Cent Sci
. 2022 Oct;
8(10):1424-1434.
PMID: 36313155
Small-molecule drug target identification is an essential and often rate-limiting step in phenotypic drug discovery and remains a major challenge. Here, we report a novel platform for target identification of...
7.
Chen J, Selvaraju M, Lin Y, Dhole S, Lin C, Sun C
J Org Chem
. 2020 Apr;
85(8):5570-5579.
PMID: 32249566
Two new classes of heteroarene-fused [1,2,4]thiadiazole and [1,2,4]selenadiazole are synthesized through the iodine-mediated [3 + 2] oxidative cyclization of 2-aminoheteroarenes and isothiocyanates/isoselenocyanates. This oxidative [3 + 2] annulation strategy is...
8.
de Azambuja F, Yang M, Feoktistova T, Selvaraju M, Brueckner A, Grove M, et al.
Nat Chem
. 2020 Mar;
12(5):489-496.
PMID: 32152476
Transition metal-catalysed C-H functionalization and decarboxylative coupling are two of the most notable synthetic strategies developed in the past 30 years. Here, we connect these two reaction pathways using bases...
9.
Lu H, Barve I, Selvaraju M, Sun C
ACS Comb Sci
. 2019 Nov;
22(1):42-48.
PMID: 31756080
A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction...
10.
Eeda V, Selvaraju M, Altman R
J Fluor Chem
. 2019 May;
218:90-98.
PMID: 31061541
Fluorinated peptidomimetics are valuable substrates for exploring peptide backbone conformations and for perturbing physicochemical properties of probe compounds. However, in some cases synthetic limitations restrict installation of the fluorinated peptidomimetics...