David K Johnson
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Explore the profile of David K Johnson including associated specialties, affiliations and a list of published articles.
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133
Citations
3764
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Recent Articles
1.
Pfannenstiel J, Duong M, Cluff D, Sherrill L, Colquhoun I, Cadoux G, et al.
bioRxiv
. 2024 Nov;
PMID: 39554145
Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target...
2.
DeCarli C, Rajan K, Jin L, Hinman J, Johnson D, Harvey D, et al.
Stroke
. 2024 Nov;
56(3):758-776.
PMID: 39545328
As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health...
3.
Myers M, Xu Z, Ryan B, DeMars Z, Ridder M, Johnson D, et al.
J Biol Chem
. 2024 Oct;
300(12):107920.
PMID: 39454961
Gram-positive bacteria utilize a Fatty Acid Kinase (FAK) complex to harvest fatty acids from the environment. This complex consists of the fatty acid kinase, FakA, and an acyl carrier protein,...
4.
Kerr C, Pfannenstiel J, Alhammad Y, OConnor J, Ghimire R, Shrestha R, et al.
J Virol
. 2024 Oct;
98(11):e0131324.
PMID: 39387584
Importance: The conserved coronavirus (CoV) macrodomain (Mac1) counters the activity of host ADP-ribosyltransferases and is critical for CoV replication and pathogenesis. As such, Mac1 is a potential therapeutic target for...
5.
Chan C, Lane K, Gao S, Adeoye-Olatunde O, Biber S, Glover C, et al.
J Alzheimers Dis
. 2024 Oct;
101(4):1167-1176.
PMID: 39365322
Background: Despite the need to increase engagement of underrepresented groups (URG) in Alzheimer's disease and related dementias (ADRD) studies, enrollment remains low. Objective: Compare referral sources across racial and ethnic...
6.
Xu W, Langhans S, Johnson D, Stauff E, Kandula V, Kecskemethy H, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273366
Angiotensin-converting enzymes (ACE) are well-known for their roles in both blood pressure regulation via the renin-angiotensin system as well as functions in fertility, immunity, hematopoiesis, and many others. The two...
7.
Hall K, Kenedy M, Johnson D, Hefty P, Akins D
PLoS One
. 2024 Aug;
19(8):e0304839.
PMID: 39208212
Lyme disease is the leading tick-borne infection in the United States, caused by the pathogenic spirochete Borreliella burgdorferi, formerly known as Borrelia burgdorferi. Diderms, or bacteria with dual-membrane ultrastructure, such...
8.
Murphy B, Wiepen J, Graham D, Swanson S, Kashipathy M, Cooper A, et al.
bioRxiv
. 2024 Aug;
PMID: 39149330
In diderm bacteria, the Lol pathway canonically mediates the periplasmic transport of lipoproteins from the inner membrane (IM) to the outer membrane (OM) and therefore plays an essential role in...
9.
Douglas J, Johnson D, Roy A, Park T
Methods Enzymol
. 2024 Jun;
698:301-342.
PMID: 38886037
Protein-protein interactions between SH2 domains and segments of proteins that include a post-translationally phosphorylated tyrosine residue (pY) underpin numerous signal transduction cascades that allow cells to respond to their environment....
10.
Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, et al.
ACS Med Chem Lett
. 2024 May;
15(5):653-658.
PMID: 38746895
Previously we identified a non-nucleotide agonist BDW568 that selectively activates the human STING allele. Here, we further characterized the mechanism of BDW568 and highlighted its potential use for selectively controlling...