Manikandan Lakshmanan
Overview
Explore the profile of Manikandan Lakshmanan including associated specialties, affiliations and a list of published articles.
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32
Citations
849
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Recent Articles
1.
Ow J, Imagawa E, Chen F, Cher W, Tung Chan S, Gurrampati R, et al.
J Hepatol
. 2025 Feb;
PMID: 39978599
Backgrounds & Aims: Citrin deficiency (CD) is an autosomal recessive urea cycle disorder caused by biallelic loss-of-function variants in the SLC25A13 gene, leading to life-threatening hyperammonemia and hypoglycemia. Variants in...
2.
Tabaglio T, Agarwal T, Cher W, Ow J, Chew A, Sun P, et al.
Mol Ther Nucleic Acids
. 2025 Feb;
36(1):102422.
PMID: 39926316
Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of therapies like small interfering RNAs, CRISPR-Cas9 guide RNAs, and GAPmers. Recent...
3.
Zhang Y, Chen K, Tang S, Cai Y, Nambu A, See Y, et al.
Nat Struct Mol Biol
. 2024 Sep;
32(1):137-149.
PMID: 39304765
Human silencers have been shown to regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated, such as whether they can form 'super-silencers' and whether...
4.
Subramanyan L, Rasheed S, Wang L, Ghosh S, Ong M, Lakshmanan M, et al.
Breast Cancer Res
. 2024 Jul;
26(1):113.
PMID: 38965558
GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is known to be essential for embryonic...
5.
Bin Masroni M, Lee K, Lee V, Ng S, Law C, Poon K, et al.
Mol Cancer
. 2023 Dec;
22(1):206.
PMID: 38093346
Background: Social behaviors such as altruism, where one self-sacrifices for collective benefits, critically influence an organism's survival and responses to the environment. Such behaviors are widely exemplified in nature but...
6.
Goh M, Fu L, Seetoh W, Koay A, Hua H, Tan S, et al.
Chemosphere
. 2023 Nov;
349:140740.
PMID: 38006918
Phthalates are extensively used as plasticizers in diverse consumer care products but have been reported to cause adverse health effects in humans. A commonly used phthalate, di-2-ethylhexylphthalate (DEHP) causes developmental...
7.
Rialdi A, Duffy M, Scopton A, Fonseca F, Zhao J, Schwarz M, et al.
Nat Cancer
. 2023 Aug;
4(8):1157-1175.
PMID: 37537299
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. β-Catenin (CTNNB1)-mutated HCC represents 30% of cases of the disease with no precision therapeutics available. Using chemical libraries derived...
8.
Zhang J, Hu Z, Chung H, Tian Y, Lau K, Ser Z, et al.
Nat Commun
. 2023 Apr;
14(1):2439.
PMID: 37117180
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex...
9.
Srinivas U, Tay N, Jaynes P, Anbuselvan A, Ramachandran G, Wardyn J, et al.
Oncogene
. 2022 May;
41(24):3382.
PMID: 35523948
No abstract available.
10.
Srinivas U, Tay N, Jaynes P, Anbuselvan A, Ramachandran G, Wardyn J, et al.
Oncogene
. 2022 Mar;
41(13):1986-2002.
PMID: 35236967
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development...