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Mallar Bhattacharya

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Citations 2257
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Recent Articles
1.
Bhattacharyya A, Yadav P, Bhattacharya M
Compr Physiol . 2025 Feb; 15(1):e70004. PMID: 39980172
Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease characterized by progressive scarring of the lung parenchyma. While two drugs have been approved by the US Food and Drug Administration...
2.
Yadav P, Ortega J, Tamaki W, Chien C, Chang K, Biswas N, et al.
bioRxiv . 2024 Aug; PMID: 39211079
Monocyte-derived macrophages recruited to injured tissues induce a maladaptive fibrotic response characterized by excessive production of collagen by local fibroblasts. Macrophages initiate this programming via paracrine factors, but it is...
3.
Bhattacharyya A, Khan R, Lee J, Tassew G, Oskouian B, Allende M, et al.
J Pathol . 2024 Feb; 263(1):22-31. PMID: 38332723
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung that leads rapidly to respiratory failure. Novel approaches to treatment are urgently needed. The bioactive lipid sphingosine-1-phosphate (S1P)...
4.
Bhattacharya M
Immunity . 2023 Aug; 56(8):1706-1708. PMID: 37557078
IL-10 has been linked to COVID-19 severity, but whether it is causal is unclear. In this issue of Immunity, Mitsui et al. find that a specific single-nucleotide polymorphism (SNP) results...
5.
Bhattacharya M, Ramachandran P
Nat Immunol . 2023 Jul; 24(9):1423-1433. PMID: 37474654
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved antifibrotics have proven modest in efficacy, and...
6.
Bhattacharya M
Am J Respir Cell Mol Biol . 2022 Jun; 67(5):520-527. PMID: 35675555
Coronavirus disease (COVID-19) begins with upper airway symptoms but proceeds in a significant proportion of patients to life-threatening infection of the lower respiratory tract, where an exuberant inflammatory response, edema,...
7.
Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen T, Tsukui T, et al.
Front Immunol . 2022 May; 13:880887. PMID: 35634278
Macrophages are paracrine signalers that regulate tissular responses to injury through interactions with parenchymal cells. Connexin hemichannels have recently been shown to mediate efflux of ATP by macrophages, with resulting...
8.
Bhattacharyya A, Boostanpour K, Bouzidi M, Magee L, Chen T, Wolters R, et al.
Am J Physiol Lung Cell Mol Physiol . 2022 Feb; 322(3):L495-L502. PMID: 35107021
Cx3cr1+ monocyte-derived macrophages (moMacs) are recruited to tissues after injury and are known to have profibrotic effects, but the cell-cell interactions and specific pathways that regulate this polarization and function...
9.
Lee S, Islam M, Boostanpour K, Aran D, Jin G, Christenson S, et al.
Nat Commun . 2021 Nov; 12(1):6309. PMID: 34728633
Lung fibrosis is increasingly detected with aging and has been associated with poor outcomes in acute lung injury or infection. However, the molecular programs driving this pro-fibrotic evolution are unclear....
10.
Arora S, Thompson P, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, et al.
Med . 2021 Oct; 2(8):938-950. PMID: 34617070
Background: The failure of immune surveillance to remove senescent cells drive age-related diseases. Here, we target an endogenous immune surveillance mechanism that can promote elimination of senescent cells and reverse...