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» Authors » Malgorzata Zygmunt

Malgorzata Zygmunt

Explore the profile of Malgorzata Zygmunt including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 52
Citations 266
Followers 0
Related Specialties
Pharmacology
Chemistry
Biochemistry
Top 10 Co-Authors
Jacek Sapa
Marek Bednarski
Barbara Filipek
Katarzyna Kiec-Kononowicz
Joanna Knutelska
Magdalena Dudek
Grazyna Chlon-Rzepa
Agata Siwek
Leszek Nowinski
Gniewomir Latacz
Published In
Pharmacol Rep
Eur J Med Chem
Arch Pharm (Weinheim)
Int J Mol Sci
Postepy Hig Med Dosw (Online)
Affiliations
Soon will be listed here.
Recent Articles
1.
The Effect of Disulfiram and N-Acetylcysteine, Potential Compensators for Sulfur Disorders, on Lipopolysaccharide-Induced Neuroinflammation Leading to Memory Impairment and the Metabolism of L-Cysteine Disturbance
Iciek M, Bilska-Wilkosz A, Gorny M, Bednarski M, Zygmunt M, Miller A, et al.
Molecules . 2025 Feb; 30(3). PMID: 39942681
Background: The role of sulfur-containing drugs, disulfiram (DSF) and N-acetylcysteine (NAC), in alleviating neuroinflammation is poorly understood. The objective of this study was to examine the effect of DSF and...
2.
The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α-Adrenoceptors Antagonists
Kaczor A, Knutelska J, Kucwaj-Brysz K, Zygmunt M, Zeslawska E, Siwek A, et al.
Int J Mol Sci . 2023 Dec; 24(23). PMID: 38068933
In order to find new hypotensive drugs possessing higher activity and better selectivity, a new series of fifteen 5,5-dimethylhydantoin derivatives (-) was designed. Three-step syntheses, consisting of N-alkylations using standard...
3.
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A and Dual A/A Receptor Affinity
Zaluski M, Lazewska D, Jasko P, Honkisz-Orzechowska E, Kuder K, Brockmann A, et al.
Int J Mol Sci . 2023 Sep; 24(18). PMID: 37762006
Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson's disease (PD). In the present study, we synthesized 25 novel xanthine derivatives with variable substituents...
4.
Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity
Zygmunt M, Slusarczyk M, Jankowska A, Swierczek A, Bryla A, Mogilski S, et al.
Pharmacol Rep . 2022 Aug; 74(5):982-997. PMID: 35930193
Background: To verify the validity of the proposed pain treatment approach, which is based on concomitant blocking of the Transient Receptor Potential Ankyrin 1 (TRPA1) channel and phosphodiesterases (PDEs) 4B/7A...
5.
An Insight into the Stages of Ion Leakage during Red Blood Cell Storage
Zimna A, Kaczmarska M, Szczesny-Malysiak E, Wajda A, Bulat K, Alcicek F, et al.
Int J Mol Sci . 2021 Apr; 22(6). PMID: 33809183
Packed red blood cells (pRBCs), the most commonly transfused blood product, are exposed to environmental disruptions during storage in blood banks. In this study, temporal sequence of changes in the...
6.
8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A receptors. Design, synthesis and biological evaluation
Zaluski M, Schabikowski J, Jasko P, Bryla A, Olejarz-Maciej A, Kaleta M, et al.
Bioorg Chem . 2020 Jul; 101:104033. PMID: 32629282
A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced...
7.
KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice
Kotanska M, Dziubina A, Szafarz M, Mika K, Regula K, Bednarski M, et al.
PLoS One . 2020 Jun; 15(6):e0229806. PMID: 32555600
The A2 adenosine receptors play an important role, among others, in the regulation of inflammatory process and glucose homeostasis in diabetes and obesity. Thus, the presented project evaluated of influence...
8.
Dual Target Ligands with 4-Butylphenoxy Scaffold as Histamine H Receptor Antagonists and Monoamine Oxidase B Inhibitors
Lazewska D, Olejarz-Maciej A, Reiner D, Kaleta M, Latacz G, Zygmunt M, et al.
Int J Mol Sci . 2020 May; 21(10). PMID: 32408504
Dual target ligands are a promising concept for the treatment of Parkinson's disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H receptor (HR) antagonism could...
9.
Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT antagonist, butyrylcholinesterase inhibitory, and antioxidant activity
Marcinkowska M, Bucki A, Panek D, Siwek A, Fajkis N, Bednarski M, et al.
Arch Pharm (Weinheim) . 2019 Jun; 352(7):e1900041. PMID: 31162703
Serotonin 5-HT receptors, butyrylcholinesterase (BuChE) and oxidative stress are related to the pathophysiology of Alzheimer's disease. Inhibition of BuChE provides symptomatic treatment of the disease and the same effect was...
10.
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies
Zaluski M, Schabikowski J, Schlenk M, Olejarz-Maciej A, Kubas B, Karcz T, et al.
Bioorg Med Chem . 2019 Feb; 27(7):1195-1210. PMID: 30808606
N9-Benzyl-substituted imidazo-, pyrimido- and 1,3-diazepino[2,1-f]purinediones were designed as dual-target-directed ligands combining A adenosine receptor (AR) antagonistic activity with blockade of monoamine oxidase B (MAO-B). A library of 37 novel compounds...