Malgorzata Mitkiewicz
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Explore the profile of Malgorzata Mitkiewicz including associated specialties, affiliations and a list of published articles.
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11
Citations
69
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Recent Articles
1.
Bronowicka-Szydelko A, Madziarska K, Kuzan A, Lewandowski L, Adamiec-Mroczek J, Pietkiewicz J, et al.
Front Mol Biosci
. 2024 Nov;
11:1484196.
PMID: 39606032
Introduction: Advanced glycation end-products (AGEs) are capable of stimulating oxidative stress and inflammation. This study investigates the synthesis of medium crosslinked AGEs (the most optimal form of AGEs because of...
2.
Leszczynska E, Makuch E, Mitkiewicz M, Jasyk I, Narita M, Gorska S, et al.
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33255528
Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation of transcription factors, such as AP-1, NF-κB, and interferon regulatory factors...
3.
Zyzak J, Mitkiewicz M, Leszczynska E, Reniewicz P, Moynagh P, Siednienko J
J Innate Immun
. 2019 Dec;
12(5):387-398.
PMID: 31851971
Innate immune response is a universal mechanism against invading pathogens. Toll-like receptors (TLRs), being part of a first line of defense, are responsible for detecting a variety of microorganisms. Among...
4.
Mitkiewicz M, Bac B, Kuropatwa M, Kurowska E, Matuszyk J, Siednienko J
Acta Biochim Pol
. 2018 Jul;
65(3):409-414.
PMID: 29959857
Cyclic guanosine monophosphate (cGMP) is synthesized by two types of enzymes: particulate (membrane-bound) guanylyl cyclases (pGCs) and soluble (cytosolic) guanylyl cyclases (sGCs). sGCs are primarily activated by binding of nitric...
5.
Matkovic K, Mitkiewicz M, Matuszyk J
Postepy Hig Med Dosw (Online)
. 2015 Aug;
69:864-73.
PMID: 26270513
Type I interferons (IFNs) are important in the immune response. After pathogen detection, host cells rapidly trigger innate immune mechanisms such as inflammatory cytokines production, thus leading to the eradication...
6.
Mitkiewicz M
Postepy Hig Med Dosw (Online)
. 2015 Apr;
69:457-68.
PMID: 25897107
Guanylyl cyclase type A (GC-A) belongs to the particulate guanylyl cyclases (pGC), which, like the soluble guanylyl cyclases (sGC), catalyze the synthesis of a common secondary messenger, namely cyclic GMP...
7.
Zablocka A, Mitkiewicz M, Macala J, Janusz M
Cell Mol Neurobiol
. 2015 Apr;
35(7):977-86.
PMID: 25841889
Neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor, as well as cytokines, for example, interleukin-6 (IL-6) play an important role in neuroprotection and in the control of...
8.
Siednienko J, Maratha A, Yang S, Mitkiewicz M, Miggin S, Moynagh P
J Biol Chem
. 2011 Nov;
286(52):44750-63.
PMID: 22065573
The induction of β-interferon (IFN-β) is a key anti-viral response to infection by RNA viruses. Virus-induced expression of IFN-β requires the co-operative action of the transcription factors IRF-3/7, NF-κB, and...
9.
Mitkiewicz M, Kuropatwa M, Kurowska E, Gorczyca W
Immunobiology
. 2010 Jul;
216(3):423-30.
PMID: 20656372
Inflammation involves the cooperation of various cells and biologically active molecules. An important intracellular messenger molecule participating in the regulation of the process is cyclic GMP (cGMP), which is synthesized...
10.
Zablocka A, Siednienko J, Mitkiewicz M, Gorczyca W, Lisowski J, Janusz M
Biomed Pharmacother
. 2009 Sep;
64(1):16-20.
PMID: 19758783
A proline-rich polypeptide complex (PRP) with immunoregulatory and procognitive activities shows beneficial effects in the Alzheimer's disease (AD). The mechanism of action of PRP is not yet fully clarified, we...