Malcolm I Mitchell
Overview
Explore the profile of Malcolm I Mitchell including associated specialties, affiliations and a list of published articles.
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30
Citations
352
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Recent Articles
1.
Gueorguieva I, Cleverly A, Desaiah D, Azaro A, Seoane J, Brana I, et al.
Drugs Context
. 2016 Dec;
5:212303.
PMID: 27990167
Objective: Galunisertib (LY2157299 monohydrate), an inhibitor of the transforming growth factor β (TGFβ) pathway, is currently under investigation in several clinical trials involving multiple tumor types. The primary objective of...
2.
Pak Y, Long A, Annes W, Witcher J, Knadler M, Ayan-Oshodi M, et al.
Drug Metab Dispos
. 2016 Nov;
45(2):137-144.
PMID: 27895114
Despite peptide transporter 1 (PEPT1) being responsible for the bioavailability for a variety of drugs, there has been little study of its potential involvement in drug-drug interactions. Pomaglumetad methionil, a...
3.
Smith D, Powderly J, Lee J, Shepard D, Wallin J, Chaudhary A, et al.
Cancer Chemother Pharmacol
. 2016 Jun;
78(2):271-80.
PMID: 27312733
Purpose: Necitumumab is a second-generation, recombinant, human immunoglobulin G1 monoclonal antibody that blocks the ligand binding site of the epidermal growth factor receptor. The primary objective of this phase 2...
4.
Satonin D, Ni X, Mitchell M, Joly H, Muram D, Small D
J Sex Med
. 2016 Jan;
13(2):187-93.
PMID: 26803453
Introduction: Testosterone 2% solution (Axiron) applied to armpit(s) is used for replacement therapy in men with a deficiency of endogenous testosterone. Aim: To determine the amount of testosterone on subjects'...
5.
Heller S, Darpo B, Mitchell M, Linnebjerg H, Leishman D, Mehrotra N, et al.
Am Heart J
. 2015 Jun;
170(1):23-35.
PMID: 26093861
Thorough QT studies conducted according to the International Council on Harmonisation E14 guideline are required for new nonantiarrhythmic drugs to assess the potential to prolong ventricular repolarization. Special considerations may...
6.
Zhang W, Mitchell M, Knadler M, Long A, Witcher J, Walling D, et al.
Int J Clin Pharmacol Ther
. 2015 Apr;
53(6):462-70.
PMID: 25881753
Objective: This thorough QT/QTc (TQT) study assessed the effects of a supratherapeutic dose of pomaglumetad methionil, a potential treatment for schizophrenia, compared to placebo on the QT interval in subjects...
7.
Annes W, Long A, Witcher J, Ayan-Oshodi M, Knadler M, Zhang W, et al.
J Pharm Sci
. 2014 Nov;
104(1):207-14.
PMID: 25382826
Pomaglumetad methionil (LY2140023) is the prodrug of a novel metabotropic glutamate 2/3 receptor agonist (LY404039) being investigated for the treatment of schizophrenia. Using accelerator mass spectrometry (AMS) and an intravenous...
8.
Small D, Ni X, Polzer P, Vart R, Satonin D, Mitchell M
J Sex Med
. 2014 Aug;
11(11):2809-17.
PMID: 25123988
Introduction: Testosterone 2% solution is applied to axillae and is indicated for testosterone replacement therapy in males deficient in endogenous testosterone. Aim: This open-label crossover study evaluated the effect of...
9.
Tham L, Fen Zhao C, Natanegara F, Lowe S, Chen C, Lim C, et al.
Int J Clin Pharmacol Ther
. 2014 Jun;
52(9):717-25.
PMID: 24887333
Objectives: A modified insulin tolerance test (ITT) can be used to simulate a physiological stress state through the induction of controlled hypoglycemia in healthy volunteers. This allows for evaluation of...
10.
Wickremsinhe E, Hynes S, Palmieri M, Mitchell M, Abraham T, Rehmel J, et al.
Xenobiotica
. 2014 Mar;
44(9):827-41.
PMID: 24666335
The disposition and metabolism of a Chk-1 inhibitor (LY2603618) was characterized following a 1-h intravenous administration of a single 250-mg dose of [14C]LY2603618 (50 µCi) to patients with advanced or...