Mahmoud S Alghamri
Overview
Explore the profile of Mahmoud S Alghamri including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
686
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0
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Recent Articles
21.
Alghamri M, Kamran N, Kadiyala P, Lowenstein P, Castro M
Methods Enzymol
. 2020 Feb;
632:215-228.
PMID: 32000897
Despite advances in uncovering the molecular mechanisms that mediate glioma progression and the implementation of novel therapeutic modalities, patients' prognosis remains dismal. This is due to both systemic and local...
22.
Altshuler D, Kadiyala P, Nunez F, Nunez F, Carney S, Alghamri M, et al.
Expert Opin Biol Ther
. 2020 Jan;
20(3):305-317.
PMID: 31959027
: The field of neuro-oncology has experienced significant advances in recent years. More is known now about the molecular and genetic characteristics of glioma than ever before. This knowledge leads...
23.
Alghamri M, Nunez F, Kamran N, Carney S, Altshuler D, Lowenstein P, et al.
Methods Enzymol
. 2020 Jan;
631:91-106.
PMID: 31948569
Diffuse Gliomas represent 80% of brain tumors with an average survival of the most aggressive form glioblastoma (GBM) 15-22 months from the time of diagnosis. The current standard of care...
24.
Nunez F, Mendez F, Kadiyala P, Alghamri M, Savelieff M, Garcia-Fabiani M, et al.
Sci Transl Med
. 2019 Feb;
11(479).
PMID: 30760578
Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1 (IDH1) are younger at diagnosis and live longer. mutations co-occur with other molecular lesions, such as 1p/19q codeletion,...
25.
Kamran N, Alghamri M, Nunez F, Shah D, Asad A, Candolfi M, et al.
Immunotherapy
. 2018 Feb;
10(4):317-339.
PMID: 29421984
There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects...
26.
Kamran N, Li Y, Sierra M, Alghamri M, Kadiyala P, Appelman H, et al.
Oncoimmunology
. 2018 Feb;
7(3):e1408750.
PMID: 29399415
Tumors are associated with expansion of immunosuppressive cells such as tumor associated macrophages (TAMs), regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs). These cells promote tumor growth, angiogenesis,...
27.
Kotha P, Sharma P, Kolawole A, Yan R, Alghamri M, Brockman T, et al.
PLoS Pathog
. 2015 Mar;
11(3):e1004696.
PMID: 25768646
Prevention of viral-induced respiratory disease begins with an understanding of the factors that increase or decrease susceptibility to viral infection. The primary receptor for most adenoviruses is the coxsackievirus and...
28.
Alghamri M, Morris M, Meszaros J, Elased K, Grobe N
Am J Physiol Heart Circ Physiol
. 2014 Jan;
306(7):H1032-40.
PMID: 24464749
Aminopeptidase-A (APA) is a less well-studied enzyme of the renin-angiotensin system. We propose that it is involved in cardiac angiotensin (ANG) metabolism and its pathologies. ANG-(1-7) can ameliorate remodeling after...
29.
Alghamri M, Weir N, Anstadt M, Elased K, Gurley S, Morris M
J Cardiovasc Pharmacol Ther
. 2012 Oct;
18(2):138-51.
PMID: 23043153
Angiotensin-converting enzyme 2 (ACE2) is present in the heart and thought to exert protective functions. We conducted studies in ACE2 deficient mice to determine whether enzyme loss would exacerbate the...