Mahadevaiah Umashankar
Overview
Explore the profile of Mahadevaiah Umashankar including associated specialties, affiliations and a list of published articles.
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11
Citations
401
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Recent Articles
1.
Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, et al.
PLoS Pathog
. 2016 May;
12(5):e1005655.
PMID: 27218650
Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), a ubiquitous β-herpesvirus, coordinates...
2.
Bughio F, Umashankar M, Wilson J, Goodrum F
J Virol
. 2015 Apr;
89(13):6536-50.
PMID: 25878111
Unlabelled: Endothelial cells (ECs) are a critical target of viruses, and infection of the endothelium represents a defining point in viral pathogenesis. Human cytomegalovirus (HCMV), the prototypical betaherpesvirus, encodes proteins...
3.
Caviness K, Cicchini L, Rak M, Umashankar M, Goodrum F
J Virol
. 2014 Oct;
88(24):14412-25.
PMID: 25297993
Unlabelled: Human cytomegalovirus (HCMV) is a complex DNA virus with a 230-kb genome encoding 170 and up to 750 proteins. The upper limit of this coding capacity suggests the evolution...
4.
Umashankar M, Goodrum F
Methods Mol Biol
. 2014 Mar;
1119:99-112.
PMID: 24639220
Of the many research challenges posed by human cytomegalovirus latency, perhaps the most notable is the requirement for primary hematopoietic cell culture. Culturing hematopoietic subpopulations while maintaining physiological relevance must...
5.
Li G, Rak M, Nguyen C, Umashankar M, Goodrum F, Kamil J
J Virol
. 2014 Mar;
88(11):6047-60.
PMID: 24623439
Unlabelled: We report that UL133-UL138 (UL133/8), a transcriptional unit within the ULb' region (ULb') of the human cytomegalovirus (HCMV) genome, and UL97, a viral protein kinase encoded by HCMV, play...
6.
Umashankar M, Rak M, Bughio F, Zagallo P, Caviness K, Goodrum F
J Virol
. 2014 Mar;
88(11):5987-6002.
PMID: 24623432
Unlabelled: The mechanisms by which viruses persist and particularly those by which viruses actively contribute to their own latency have been elusive. Here we report the existence of opposing functions...
7.
Petrucelli A, Umashankar M, Zagallo P, Rak M, Goodrum F
J Virol
. 2012 Jun;
86(16):8653-62.
PMID: 22674978
We previously described a novel genetic locus within the ULb' region of the human cytomegalovirus (HCMV) genome that, while dispensable for replication in fibroblasts, suppresses replication in hematopoietic progenitors and...
8.
Umashankar M, Petrucelli A, Cicchini L, Caposio P, Kreklywich C, Rak M, et al.
PLoS Pathog
. 2012 Jan;
7(12):e1002444.
PMID: 22241980
Clinical strains of HCMV encode 20 putative ORFs within a region of the genome termed ULb' that are postulated to encode functions related to persistence or immune evasion. We have...
9.
Zheng A, Umashankar M, Kielian M
PLoS Pathog
. 2010 Oct;
6(10):e1001157.
PMID: 20975939
Flaviviruses bud into the endoplasmic reticulum and are transported through the secretory pathway, where the mildly acidic environment triggers particle rearrangement and allows furin processing of the prM protein to...
10.
Palucha A, Loniewska A, Satheshkumar S, Boguszewska-Chachulska A, Umashankar M, Milner M, et al.
Prog Nucleic Acid Res Mol Biol
. 2005 Sep;
80:135-68.
PMID: 16164974
No abstract available.