Magdalena N Renno
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Explore the profile of Magdalena N Renno including associated specialties, affiliations and a list of published articles.
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10
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32
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Recent Articles
1.
de Souza L, Salustiano E, da Costa K, Costa A, Rumjanek V, Domingos J, et al.
Bioorg Chem
. 2021 Mar;
110:104790.
PMID: 33743223
α-aryl-α-tetralones and α-fluoro-α-aryl-α-tetralones derivatives were synthesized by palladium catalyzed α-arylation reaction of α-tetralones and α-fluoro-α-tetralones, with bromoarenes in moderate to good yields. These compounds were evaluated for their in vitro...
2.
de Souza L, Moraes P, Leao R, Costa P, Soares R, Pascutti P, et al.
Comput Biol Chem
. 2020 Jun;
87:107293.
PMID: 32559640
Currently Alzheimer's disease (AD) is a devastating neurological disorder that mainly affects the elderly. The treatment of AD has as main objective to increase the levels of ACh in the...
3.
de Lima E, Castelo-Branco F, Maquiaveli C, Farias A, Renno M, Boechat N, et al.
Bioorg Med Chem
. 2019 Jul;
27(17):3853-3859.
PMID: 31311700
Searching for new substances with antileishmanial activity, we synthesized and evaluated a series of α,α-difluorohydrazide and α,α-difluoramides against Leishmania amazonensis arginase (LaArg). Four α,α-difluorohydrazide derivatives showed activity against LaArg with...
4.
Mendes J, Salustiano E, Pires C, Oliveira T, Barcellos J, Cifuentes J, et al.
Bioorg Chem
. 2018 Jul;
80:585-590.
PMID: 30036814
11a-N-tosyl-5-carbapterocarpans (5a-c and 6a-c), 9-N-tosyl-4,4a,9,9a-tetrahydro-3H-carbazole (7), 11a-N-tosyl-5-carbapterocarpen (8) analogues of LQB-223 (4a), were synthesized through palladium catalyzed azaarylation of substituted dihydronaphtalenes (14a-c) and cyclohexadiene (15), respectively, with N-tosyl-o-iodoaniline (11). In...
5.
Rica I, Netto C, Renno M, Abreu P, Costa P, da Silva A, et al.
Bioorg Med Chem
. 2016 Aug;
24(18):4415-4423.
PMID: 27492193
Pterocarpanquinone (+/-)-LQB-118 presents antineoplastic and antiparasitic properties and also shows great inhibitory effect on TNF-α release in vitro. Here, its anti-inflammatory activity was evaluated in a lipopolysaccharide (LPS)-induced lung inflammation...
6.
Oliveira A, Renno M, de Matos C, Bertuzzi M, Ramalho T, Fraga C, et al.
J Biomol Struct Dyn
. 2011 Aug;
29(2):351-67.
PMID: 21875154
Considering the risk represented by plague today as a potential biological warfare agent, we propose cytosolic Yersinia pestis dihydrofolate reductase (YpDHFR) as a new target to the design of selective...
7.
Cortopassi W, Oliveira A, Guimaraes A, Renno M, Krettli A, Franca T
J Biomol Struct Dyn
. 2011 Jun;
29(1):207-18.
PMID: 21696234
The literature has reported that ferriprotoporphyrin IX (hematin) intoxicates the malarial parasite through competition with NADH for the active site of the enzyme lactate dehydrogenase (LDH). In order to avoid...
8.
Ramalho T, Tanos C, Renno M, Guimaraes A, da Cunha E, Kuca K
Chem Biol Interact
. 2010 Aug;
187(1-3):436-40.
PMID: 20685354
In this work a theoretical methodology for evaluation of the association and kinetic reactivation constants of oximes using the Molegro and Spartan softwares was proposed and validated facing in vitro...
9.
Ramalho T, Franca T, Renno M, Guimaraes A, da Cunha E, Kuca K
Chem Biol Interact
. 2010 Mar;
185(1):73-7.
PMID: 20188081
In this work a theoretical methodology for evaluation of the association and kinetic reactivation constants of oximes using the Molegro and Spartan softwares was proposed and validated facing in vitro...
10.
Renno M, Barbosa G, Zancan P, Veiga V, Alviano C, Sola-Penna M, et al.
An Acad Bras Cienc
. 2008 Sep;
80(3):467-76.
PMID: 18797799
Plant-derived substances have been considered as important sources of drugs, including antineoplasic agents. Babassu mesocarp is popularly used in Brazil as a food additive, and in popular medicine against several...