Magali Bebien
Overview
Explore the profile of Magali Bebien including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
12
Citations
1094
Followers
0
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Recent Articles
1.
Goossens P, Rodriguez-Vita J, Etzerodt A, Masse M, Rastoin O, Gouirand V, et al.
Cell Metab
. 2019 Apr;
29(6):1376-1389.e4.
PMID: 30930171
Macrophages possess intrinsic tumoricidal activity, yet tumor-associated macrophages (TAMs) rapidly adopt an alternative phenotype within the tumor microenvironment that is marked by tumor-promoting immunosuppressive and trophic functions. The mechanisms that...
2.
Habbeddine M, Verthuy C, Rastoin O, Chasson L, Bebien M, Bajenoff M, et al.
Cell Rep
. 2017 Nov;
21(9):2515-2527.
PMID: 29186688
The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) in the spleen marginal zone capture microbial antigens to trigger adaptive immune responses....
3.
Etzerodt A, Berg R, Plovsing R, Andersen M, Bebien M, Habbeddine M, et al.
Sci Rep
. 2017 Jan;
7:40286.
PMID: 28084321
CD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human receptor can be shed from the macrophage surface owing to a cleavage site for the inflammation-inducible TACE/ADAM17 enzyme....
4.
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, et al.
EMBO J
. 2013 Feb;
32(6):816-28.
PMID: 23422957
Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T...
5.
Bebien M, Hensler M, Davanture S, Hsu L, Karin M, Park J, et al.
PLoS Pathog
. 2012 Jul;
8(7):e1002812.
PMID: 22829768
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune-compromised adults. The pore-forming toxin (PFT) β hemolysin/cytolysin (βh/c) is a major virulence factor...
6.
Fong C, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, et al.
J Exp Med
. 2008 May;
205(6):1269-76.
PMID: 18490491
The nuclear factor kappaB (NF-kappaB) pathway plays a central role in inflammation and immunity. In response to proinflammatory cytokines and pathogen-associated molecular patterns, NF-kappaB activation is controlled by IkappaB kinase...
7.
Didierlaurent A, Goulding J, Patel S, Snelgrove R, Low L, Bebien M, et al.
J Exp Med
. 2008 Jan;
205(2):323-9.
PMID: 18227219
The World Health Organization estimates that lower respiratory tract infections (excluding tuberculosis) account for approximately 35% of all deaths caused by infectious diseases. In many cases, the cause of death...
8.
Lawrence T, Bebien M, Liu G, Nizet V, Karin M
Nature
. 2005 Apr;
434(7037):1138-43.
PMID: 15858576
Inflammation and innate immunity involve signalling pathways leading to the production of inflammatory mediators. Usually such responses are self-limiting, but aberrant resolution of inflammation results in chronic diseases. Much attention...
9.
Bonizzi G, Bebien M, Otero D, Johnson-Vroom K, Cao Y, Vu D, et al.
EMBO J
. 2004 Oct;
23(21):4202-10.
PMID: 15470505
IkappaB Kinase (IKK)alpha is required for activation of an alternative NF-kappaB signaling pathway based on processing of the NF-kappaB2/p100 precursor protein, which associates with RelB in the cytoplasm. This pathway,...
10.
Bebien M, Salinas S, Becamel C, Richard V, Linares L, Hipskind R
Oncogene
. 2003 Mar;
22(12):1836-47.
PMID: 12660819
Cellular stress activates multiple mitogen-activated protein kinase (MAPK) cascades and immediate-early gene (IEG) transcription. To address how these events are linked, we investigated the endogenous signaling/transcription factor network driving IEG...