Madhu P Sirivelu
Overview
Explore the profile of Madhu P Sirivelu including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
191
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0
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Recent Articles
1.
Tyszkiewicz C, Hwang S, DaSilva J, Kovi R, Fader K, Sirivelu M, et al.
Neurotoxicology
. 2024 Feb;
101:46-53.
PMID: 38316190
Adeno-associated virus (AAV)-based vectors are commonly used for delivering transgenes in gene therapy studies, but they are also known to cause dorsal root ganglia (DRG) and peripheral nerve toxicities in...
2.
Poitout-Belissent F, Vitsky A, Smith M, Sirivelu M
Toxicol Pathol
. 2022 Oct;
50(7):867-870.
PMID: 36305575
Hematology and bone marrow analysis is central to our understanding of the hematopoietic system and how it responds to insults, and this session presented during the 2022 STP symposium provided...
3.
Fader K, Pardo I, Kovi R, Somps C, Wang H, Vaidya V, et al.
Mol Ther Methods Clin Dev
. 2022 May;
25:264-277.
PMID: 35505662
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration. As...
4.
Clark K, Shin A, Sirivelu M, MohanKumar R, Maddineni S, Ramachandran R, et al.
Int J Mol Sci
. 2021 Dec;
22(24).
PMID: 34947993
Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic-pituitary-adrenal (HPA) axis. We have reported previously that daily leptin injections help to alleviate these symptoms. Therefore,...
5.
Palazzi X, Pardo I, Sirivelu M, Newman L, Kumpf S, Qian J, et al.
Hum Gene Ther
. 2021 Dec;
33(3-4):175-187.
PMID: 34931542
Recombinant adeno-associated viruses (AAVs) have emerged as promising vectors for human gene therapy, but some variants have induced severe toxicity in Rhesus monkeys and piglets following high-dose intravenous (IV) administration....
6.
Shin A, MohanKumar S, Balasubramanian P, Sirivelu M, Linning K, Woolcock A, et al.
Nutr Diabetes
. 2019 Mar;
9(1):10.
PMID: 30886140
Background/objectives: Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated...
7.
Loria K, Beguesse K, Walsh A, Sirivelu M
J Am Vet Med Assoc
. 2017 Jun;
250(12):1387-1390.
PMID: 28569628
No abstract available.
8.
Philips B, Loria K, Sirivelu M, Jaber S, Allen-Worthington K, Veeder C, et al.
J Am Vet Med Assoc
. 2016 Sep;
249(7):755-7.
PMID: 27654161
No abstract available.
9.
Zhao A, Tu L, Mukai C, Sirivelu M, Pillai V, Morohaku K, et al.
J Biol Chem
. 2015 Dec;
291(4):1591-1603.
PMID: 26627829
Function of the mammalian translocator protein (TSPO; previously known as the peripheral benzodiazepine receptor) remains unclear because its presumed role in steroidogenesis and mitochondrial permeability transition established using pharmacological methods...
10.
Basson M, Zeng B, Downey C, Sirivelu M, Tepe J
Mol Oncol
. 2014 Dec;
9(2):513-26.
PMID: 25454347
Large tumors exhibit high interstitial pressure heightened by growth against the constraining stroma. Such pressures could stimulate tumor proliferation via a mechanosensitive ion channel. We studied the effects of 0-80...