Mackenzie W Amoroso
Overview
Explore the profile of Mackenzie W Amoroso including associated specialties, affiliations and a list of published articles.
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7
Citations
1385
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0
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Recent Articles
1.
Cohen J, Amoroso M, Uchida N
Elife
. 2015 Feb;
4.
PMID: 25714923
Serotonin's function in the brain is unclear. One challenge in testing the numerous hypotheses about serotonin's function has been observing the activity of identified serotonergic neurons in animals engaged in...
2.
Re D, Le Verche V, Yu C, Amoroso M, Politi K, Phani S, et al.
Neuron
. 2014 Feb;
81(5):1001-1008.
PMID: 24508385
Most cases of neurodegenerative diseases are sporadic, hindering the use of genetic mouse models to analyze disease mechanisms. Focusing on the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS), we...
3.
Amoroso M, Croft G, Williams D, OKeeffe S, Carrasco M, Davis A, et al.
J Neurosci
. 2013 Jan;
33(2):574-86.
PMID: 23303937
Human pluripotent stem cells are a promising source of differentiated cells for developmental studies, cell transplantation, disease modeling, and drug testing. However, their widespread use even for intensely studied cell...
4.
Takazawa T, Croft G, Amoroso M, Studer L, Wichterle H, MacDermott A
PLoS One
. 2012 Jul;
7(7):e40154.
PMID: 22802953
Our understanding of motor neuron biology in humans is derived mainly from investigation of human postmortem tissue and more indirectly from live animal models such as rodents. Thus generation of...
5.
Nedelec S, Peljto M, Shi P, Amoroso M, Kam L, Wichterle H
J Neurosci
. 2012 Jan;
32(4):1496-506.
PMID: 22279234
Formation of functional motor circuits relies on the ability of distinct spinal motor neuron subtypes to project their axons with high precision to appropriate muscle targets. While guidance cues contributing...
6.
Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith Z, et al.
Cell
. 2011 Feb;
144(3):439-52.
PMID: 21295703
The developmental potential of human pluripotent stem cells suggests that they can produce disease-relevant cell types for biomedical research. However, substantial variation has been reported among pluripotent cell lines, which...
7.
Boulting G, Kiskinis E, Croft G, Amoroso M, Oakley D, Wainger B, et al.
Nat Biotechnol
. 2011 Feb;
29(3):279-86.
PMID: 21293464
Human induced pluripotent stem cells (iPSCs) present exciting opportunities for studying development and for in vitro disease modeling. However, reported variability in the behavior of iPSCs has called their utility...