Stephane Nedelec
Overview
Explore the profile of Stephane Nedelec including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
816
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0
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Recent Articles
1.
Mirdass C, Catala M, Bocel M, Nedelec S, Ribes V
Emerg Top Life Sci
. 2023 Dec;
7(4):423-437.
PMID: 38087891
Neurulation is a critical step in early embryonic development, giving rise to the neural tube, the primordium of the central nervous system in amniotes. Understanding this complex, multi-scale, multi-tissue morphogenetic...
2.
Gribaudo S, Robert R, van Sambeek B, Mirdass C, Lyubimova A, Bouhali K, et al.
Nat Biotechnol
. 2023 Sep;
42(8):1243-1253.
PMID: 37709912
Integrated in vitro models of human organogenesis are needed to elucidate the multi-systemic events underlying development and disease. Here we report the generation of human trunk-like structures that model the...
3.
Liau E, Jin S, Chen Y, Liu W, Calon M, Nedelec S, et al.
Nat Commun
. 2023 Jan;
14(1):46.
PMID: 36596814
Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate movements. In vertebrates, the molecular identities of the cardinal MN types such as those innervating limb versus trunk...
4.
Mouilleau V, Vaslin C, Robert R, Gribaudo S, Nicolas N, Jarrige M, et al.
Development
. 2021 Mar;
148(6).
PMID: 33782043
Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether the pace of sequential activation of HOX...
5.
Nedelec S, Martinez-Arias A
Curr Opin Neurobiol
. 2021 Mar;
66:240-249.
PMID: 33677159
The connectivity patterns of neurons sustaining the functionality of spinal locomotor circuits rely on the specification of hundreds of motor neuron and interneuron subtypes precisely arrayed within the embryonic spinal...
6.
Kumamoto T, Maurinot F, Barry-Martinet R, Vaslin C, Vandormael-Pournin S, Le M, et al.
Neuron
. 2020 Jun;
107(4):617-630.e6.
PMID: 32559415
Stable genomic integration of exogenous transgenes is essential in neurodevelopmental and stem cell studies. Despite tools driving increasingly efficient genomic insertion with DNA vectors, transgenesis remains fundamentally hindered by the...
7.
Duval N, Vaslin C, Barata T, Frarma Y, Contremoulins V, Baudin X, et al.
Development
. 2019 Jun;
146(14).
PMID: 31239243
Bone morphogenetic proteins (BMPs) are secreted regulators of cell fate in several developing tissues. In the embryonic spinal cord, they control the emergence of the neural crest, roof plate and...
8.
9.
Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, et al.
Nat Biotechnol
. 2014 Nov;
33(1):89-96.
PMID: 25383599
Specification of cell identity during development depends on exposure of cells to sequences of extrinsic cues delivered at precise times and concentrations. Identification of combinations of patterning molecules that control...
10.
Mazzoni E, Mahony S, Closser M, Morrison C, Nedelec S, Williams D, et al.
Nat Neurosci
. 2013 Jul;
16(9):1219-27.
PMID: 23872598
Efficient transcriptional programming promises to open new frontiers in regenerative medicine. However, mechanisms by which programming factors transform cell fate are unknown, preventing more rational selection of factors to generate...