Maciej S Lesniak
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Explore the profile of Maciej S Lesniak including associated specialties, affiliations and a list of published articles.
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254
Citations
9509
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Recent Articles
11.
Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu W, et al.
Nat Commun
. 2024 Mar;
15(1):1987.
PMID: 38443336
Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs macrophage...
12.
Tripathi S, Najem H, Dussold C, Pacheco S, Miska J, McCortney K, et al.
J Clin Invest
. 2024 Feb;
134(4).
PMID: 38357919
No abstract available.
13.
Rashidi A, Billingham L, Zolp A, Chia T, Silvers C, Katz J, et al.
Cell Metab
. 2023 Dec;
36(1):62-77.e8.
PMID: 38134929
Glioblastoma (GBM) is a malignancy dominated by the infiltration of tumor-associated myeloid cells (TAMCs). Examination of TAMC metabolic phenotypes in mouse models and patients with GBM identified the de novo...
14.
Fares J, Petrosyan E, Kanojia D, Dmello C, Cordero A, Duffy J, et al.
J Clin Invest
. 2023 Oct;
133(24).
PMID: 37847564
A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Using a CNS small-molecule inhibitor library of 320 agents known to be blood-brain...
15.
Chojak R, Fares J, Petrosyan E, Lesniak M
J Neurooncol
. 2023 Jul;
164(1):11-29.
PMID: 37458855
Introduction: Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which...
16.
Petrosyan E, Fares J, Lesniak M, Koski T, El Tecle N
Trends Mol Med
. 2023 Jun;
29(9):740-752.
PMID: 37349248
The global aging population has led to an increase in geriatric diseases, including adult degenerative scoliosis (ADS). ADS is a spinal deformity affecting adults, particularly females. It is characterized by...
17.
Sonabend A, Gould A, Amidei C, Ward R, Schmidt K, Zhang D, et al.
Lancet Oncol
. 2023 May;
24(5):509-522.
PMID: 37142373
Background: Low-intensity pulsed ultrasound with concomitant administration of intravenous microbubbles (LIPU-MB) can be used to open the blood-brain barrier. We aimed to assess the safety and pharmacokinetics of LIPU-MB to...
18.
Zhang P, Rashidi A, Zhao J, Silvers C, Wang H, Castro B, et al.
Nat Commun
. 2023 Mar;
14(1):1610.
PMID: 36959214
As a key component of the standard of care for glioblastoma, radiotherapy induces several immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging these radiotherapy-elicited processes, we...
19.
Dmello C, Zhao J, Chen L, Gould A, Castro B, Arrieta V, et al.
Nat Commun
. 2023 Mar;
14(1):1566.
PMID: 36949040
Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 T cell mediated killing are less...
20.
Ellingwood A, Wan H, Lee-Chang C, Lesniak M, Zhang P
Mat Matters (Milwaukee)
. 2023 Feb;
17(2):29-36.
PMID: 36789150
No abstract available.