M Yusuf Ali
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Explore the profile of M Yusuf Ali including associated specialties, affiliations and a list of published articles.
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25
Citations
636
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Recent Articles
1.
Ali M, Lu H, Fagnant P, Macfarlane J, Trybus K
bioRxiv
. 2025 Jan;
PMID: 39868150
The folded auto-inhibited state of kinesin-1 is stabilized by multiple weak interactions and binds weakly to microtubules. Here we investigate the extent to which homodimeric kinesin-1 lacking light chains is...
2.
Gibson J, Zhao X, Ali M, Solmaz S, Wang C
Biomolecules
. 2023 Oct;
13(10).
PMID: 37892127
Dynein motors facilitate the majority of minus-end-directed transport events on microtubules. The dynein adaptor Bicaudal D2 (BicD2) recruits the dynein machinery to several cellular cargo for transport, including Nup358, which...
3.
Gibson J, Cui H, Ali M, Zhao X, Debler E, Zhao J, et al.
Elife
. 2022 Mar;
11.
PMID: 35229716
Nup358, a protein of the nuclear pore complex, facilitates a nuclear positioning pathway that is essential for many biological processes, including neuromuscular and brain development. Nup358 interacts with the dynein...
4.
Michalek A, Ali M
Biochem Biophys Rep
. 2022 Jan;
29:101194.
PMID: 35024461
High-resolution experiments revealed that a single myosin-Va motor can transport micron-sized cargo on actin filaments in a stepwise manner. However, intracellular cargo transport is mediated through the dense actin meshwork...
5.
Cui H, Ali M, Goyal P, Zhang K, Loh J, Trybus K, et al.
Traffic
. 2020 May;
21(7):463-478.
PMID: 32378283
The dynein adaptor Drosophila Bicaudal D (BicD) is auto-inhibited and activates dynein motility only after cargo is bound, but the underlying mechanism is elusive. In contrast, we show that the...
6.
Emran S, Krupnik T, Kumar V, Ali M, Pittelkow C
Field Crops Res
. 2019 Sep;
241:107567.
PMID: 31534298
Farmers in low-elevation coastal zones in South Asia face numerous food security and environmental sustainability challenges. This study evaluated the effects of nitrogen (N) rate and source on the agronomic,...
7.
Sladewski T, Billington N, Ali M, Bookwalter C, Lu H, Krementsova E, et al.
Elife
. 2018 Jun;
7.
PMID: 29944116
We investigated the role of full-length Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA...
8.
Lombardo A, Nelson S, Ali M, Kennedy G, Trybus K, Walcott S, et al.
Nat Commun
. 2017 Jun;
8:15692.
PMID: 28569841
Intracellular cargo transport relies on myosin Va molecular motor ensembles to travel along the cell's three-dimensional (3D) highway of actin filaments. At actin filament intersections, the intersecting filament is a...
9.
Krementsova E, Furuta K, Oiwa K, Trybus K, Ali M
J Biol Chem
. 2017 May;
292(26):10998-11008.
PMID: 28476885
Myosin Vc (myoVc) is unique among vertebrate class V myosin isoforms in that it requires teams of motors to move continuously on single actin filaments. Single molecules of myoVc cannot...
10.
Ali M, Vilfan A, Trybus K, Warshaw D
Biophys J
. 2016 Nov;
111(10):2228-2240.
PMID: 27851945
Myosin Va (myoVa) is a processive, actin-based molecular motor essential for intracellular cargo transport. When a cargo is transported by an ensemble of myoVa motors, each motor faces significant physical...