M van de Wetering
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Explore the profile of M van de Wetering including associated specialties, affiliations and a list of published articles.
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34
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3207
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Recent Articles
11.
Staal F, Burgering B, van de Wetering M, Clevers H
Int Immunol
. 1999 Apr;
11(3):317-23.
PMID: 10221643
Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade. Recently, members of the...
12.
Van Es J, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, et al.
Curr Biol
. 1999 Feb;
9(2):105-8.
PMID: 10021369
The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. Complex formation induces the rapid...
13.
Zhang Z, Hartmann H, Do V, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, et al.
Nature
. 1998 Oct;
395(6703):698-702.
PMID: 9790190
Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of...
14.
Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, et al.
Nature
. 1998 Oct;
395(6702):608-12.
PMID: 9783587
Tcf/Lef transcription factors mediate signalling from Wingless/Wnt proteins by recruiting Armadillo/beta-catenin as a transcriptional co-activator. However, studies of Drosophila, Xenopus and Caenorhabditis elegans have indicated that Tcf factors may also...
15.
Dooijes D, van Beest M, van de Wetering M, Boulanger G, Jones T, Clevers H, et al.
Mol Gen Genet
. 1998 Jun;
258(1-2):45-52.
PMID: 9613571
We previously described the molecular cloning of a mammalian T cell factor 1 (TCF-1)-like protein from Drosophila melanogaster, encoded by the pangolin (pan) locus, and demonstrated that it consists of...
16.
Clevers H, van de Wetering M
Trends Genet
. 1998 Jan;
13(12):485-9.
PMID: 9433138
Factors of the TCF/LEF HMG domain family (TCFs) exist in vertebrates, Drosophila melanogaster and Caenorhabditis elegans. It has very recently become evident that TCFs interact with the vertebrate WNT effector...
17.
van de Wetering M, Cavallo R, Dooijes D, van Beest M, van Es J, Loureiro J, et al.
Cell
. 1997 Mar;
88(6):789-99.
PMID: 9118222
The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have cloned a maternally expressed...
18.
Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, et al.
Cell
. 1996 Aug;
86(3):391-9.
PMID: 8756721
XTcf-3 is a maternally expressed Xenopus homolog of the mammalian HMG box factors Tcf-1 and Lef-1. The N-terminus of XTcf-3 binds to beta-catenin. Microinjection of XTcf-3 mRNA in embryos results...
19.
Schilham M, Oosterwegel M, Moerer P, Ya J, de Boer P, van de Wetering M, et al.
Nature
. 1996 Apr;
380(6576):711-4.
PMID: 8614465
A striking example of the relationship between regulation of transcription and phenotype is the central role of the Y-chromosomal gene Sry in mammalian sex determination. Sry is the founding member...
20.
van de Wetering M, Castrop J, Korinek V, Clevers H
Mol Cell Biol
. 1996 Mar;
16(3):745-52.
PMID: 8622675
Previously, we reported the isolation of cDNA clones representing four alternative splice forms of TCF-1, a T-cell-specific transcription factor. In the present study, Western blotting (immunoblotting) yielded a multitude of...