M Sloan Siegrist
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Explore the profile of M Sloan Siegrist including associated specialties, affiliations and a list of published articles.
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38
Citations
1074
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Recent Articles
1.
Lepori I, Liu Z, Evbarunegbe N, Feng S, Brown T, Mane K, et al.
bioRxiv
. 2025 Mar;
PMID: 40060676
Tuberculosis (TB), caused by (Mtb), is the deadliest single-agent infection worldwide. Current antibiotic treatment for TB takes a minimum of four months, underscoring the need for better therapeutics. The unique...
2.
Ongwae G, Liu Z, Feng S, Chordia M, Sharifian Gh M, Dash R, et al.
bioRxiv
. 2025 Mar;
PMID: 40027664
Gram-negative bacterial pathogens pose a significant challenge in drug development due to their outer membranes, which impede the permeation of small molecules. The lack of widely adoptable methods to measure...
3.
Dash R, Liu Z, Lepori I, Chordia M, Ocius K, Holsinger K, et al.
bioRxiv
. 2025 Jan;
PMID: 39868157
The mycomembrane of mycobacteria has long been regarded as the primary barrier to the accumulation of molecules within these bacteria. Understanding accumulation beyond the mycomembrane of () is crucial for...
4.
Lepori I, Jackson K, Liu Z, Chordia M, Wong M, Rivera S, et al.
bioRxiv
. 2025 Jan;
PMID: 39803531
Abstract Graphic:
5.
Santamaria C, Biegas K, Kim C, Cabral J, Lee J, Swarts B, et al.
bioRxiv
. 2025 Jan;
PMID: 39763847
Significance Statement: Glycolipids from the cell envelope, particularly trehalose dimycolate (TDM), play key roles in subverting the immune response to this intracellular pathogen. How subversion occurs is often unclear because...
6.
Lepori I, Roncetti M, Vitiello M, Barresi E, De Paolo R, Tentori P, et al.
ACS Chem Biol
. 2024 Sep;
19(10):2131-2140.
PMID: 39317359
Among bacteria used as anticancer vaccines, attenuated (Lm) stands out, because it spreads from one infected cancer cell to the next, induces a strong adaptive immune response, and is suitable...
7.
Kado T, Akbary Z, Motooka D, Sparks I, Melzer E, Nakamura S, et al.
Elife
. 2023 Sep;
12.
PMID: 37665120
Lateral partitioning of proteins and lipids shapes membrane function. In model membranes, partitioning can be influenced both by bilayer-intrinsic factors like molecular composition and by bilayer-extrinsic factors such as interactions...
8.
Xu Z, Gamble A, Niu W, Smith M, Siegrist M, Tuominen M, et al.
Langmuir
. 2023 Apr;
39(18):6387-6398.
PMID: 37053037
When bacteria adhere to surfaces, the chemical and mechanical character of the cell-substrate interface guides cell function and the development of microcolonies and biofilms. Alternately on bactericidal surfaces, intimate contact...
9.
Prithviraj M, Kado T, Mayfield J, Young D, Huang A, Motooka D, et al.
mBio
. 2023 Mar;
14(2):e0339622.
PMID: 36976029
The intracellular membrane domain (IMD) is a laterally discrete region of the mycobacterial plasma membrane, enriched in the subpolar region of the rod-shaped cell. Here, we report genome-wide transposon sequencing...
10.
Liu Z, Lepori I, Chordia M, Dalesandro B, Guo T, Dong J, et al.
Angew Chem Int Ed Engl
. 2023 Jan;
62(20):e202217777.
PMID: 36700874
The general lack of permeability of small molecules observed for Mycobacterium tuberculosis (Mtb) is most ascribed to its unique cell envelope. More specifically, the outer mycomembrane is hypothesized to be...