M R Ehlers
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Explore the profile of M R Ehlers including associated specialties, affiliations and a list of published articles.
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35
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Recent Articles
11.
Ehlers M
Microbes Infect
. 2000 Apr;
2(3):289-94.
PMID: 10758405
CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3...
12.
Schwager S, Chubb A, Scholle R, Brandt W, Mentele R, Riordan J, et al.
Biochemistry
. 1999 Aug;
38(32):10388-97.
PMID: 10441133
The role of juxtamembrane stalk glycosylation in modulating stalk cleavage and shedding of membrane proteins remains unresolved, despite reports that proteins expressed in glycosylation-deficient cells undergo accelerated proteolysis. We have...
13.
Schwager S, Chubb A, Scholle R, Brandt W, Eckerskorn C, Sturrock E, et al.
Biochemistry
. 1998 Nov;
37(44):15449-56.
PMID: 9799507
Specialized proteases, referred to as sheddases, secretases, or membrane-protein-solubilizing proteases (MPSPs), solubilize the extracellular domains of diverse membrane proteins by catalyzing a specific cleavage in the juxtamembrane stalk regions of...
14.
Ehlers M, Daffe M
Trends Microbiol
. 1998 Sep;
6(8):328-35.
PMID: 9746944
Mycobacterium tuberculosis has evolved successful strategies to invade and persist within macrophages. Intimate pathogen-macrophage contacts dictate receptor choice and probably specify the intracellular fate of these microorganisms. Binding to specific...
15.
Cywes C, Hoppe H, Daffe M, Ehlers M
Infect Immun
. 1997 Oct;
65(10):4258-66.
PMID: 9317035
The choice of host cell receptor and the mechanism of binding (opsonic versus nonopsonic) may influence the intracellular fate of Mycobacterium tuberculosis. We have identified two substrains of M. tuberculosis...
16.
Hoppe H, de Wet B, Cywes C, Daffe M, Ehlers M
Infect Immun
. 1997 Sep;
65(9):3896-905.
PMID: 9284169
The molecular basis for the binding of Mycobacterium tuberculosis to nonphagocytic cells, which are readily infected in vitro, and the in vivo significance of this interaction are incompletely understood. Of...
17.
Ehlers M, Schwager S, Chubb A, Scholle R, Brandt W, Riordan J
Immunopharmacology
. 1997 Jun;
36(2-3):271-8.
PMID: 9228557
Diverse membrane proteins are solubilized by a specific proteolytic cleavage in the stalk sequence adjacent to the membrane anchor, with release of the extracellular domain. Examples are the amyloid precursor...
18.
Yu X, Sturrock E, Wu Z, Biemann K, Ehlers M, Riordan J
J Biol Chem
. 1997 Feb;
272(6):3511-9.
PMID: 9013598
The sites of glycosylation of Chinese hamster ovary cell expressed testicular angiotensin-converting enzyme (tACE) have been determined by matrix-assisted laser desorption ionization/time of flight/mass spectrometry of peptides generated by proteolytic...
19.
Cywes C, Godenir N, Hoppe H, Scholle R, Steyn L, KIRSCH R, et al.
Infect Immun
. 1996 Dec;
64(12):5373-83.
PMID: 8945590
Nonopsonic invasion of mononuclear phagocytes by Mycobacterium tuberculosis is likely important in the establishment of a primary infection in the lung. M. tuberculosis binds to a variety of phagocyte receptors,...
20.
Ehlers M, Schwager S, Scholle R, Manji G, Brandt W, Riordan J
Biochemistry
. 1996 Jul;
35(29):9549-59.
PMID: 8755736
Many structurally and functionally diverse membrane proteins are solubilized by a specific proteolytic cleavage in the stalk sequence adjacent to the membrane anchor, with release of the extracellular domain. Examples...