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CR3: a General Purpose Adhesion-recognition Receptor Essential for Innate Immunity

Overview
Journal Microbes Infect
Publisher Elsevier
Date 2000 Apr 12
PMID 10758405
Citations 112
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Abstract

CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.

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