M P de Caestecker
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Explore the profile of M P de Caestecker including associated specialties, affiliations and a list of published articles.
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25
Citations
962
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0
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Recent Articles
1.
Yang M, Lopez L, Brewer M, Delgado R, Menshikh A, Clouthier K, et al.
bioRxiv
. 2023 Jul;
PMID: 37398101
Graphical Abstract:
2.
Qin B, Chacko B, Lam S, de Caestecker M, Correia J, Lin K
Mol Cell
. 2002 Jan;
8(6):1303-12.
PMID: 11779505
Phosphorylation of Smad1 at the conserved carboxyl terminal SVS sequence activates BMP signaling. Here we report the crystal structure of the Smad1 MH2 domain in a conformation that reveals the...
3.
Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al.
J Biol Chem
. 2001 Mar;
276(22):19332-9.
PMID: 11279102
Sorting nexins (SNX) comprise a family of proteins with homology to several yeast proteins, including Vps5p and Mvp1p, that are required for the sorting of proteins to the yeast vacuole....
4.
Watanabe H, de Caestecker M, Yamada Y
J Biol Chem
. 2001 Mar;
276(17):14466-73.
PMID: 11278290
In chondrogenesis, members of the transforming growth factor-beta (TGF-beta) superfamily play critical roles by inducing gene expression of cartilage-specific molecules. By using a chondrogenic cell line, ATDC5, we investigated the...
5.
Lee D, Park S, Yi Y, Choi S, Lee C, Parks W, et al.
Genes Dev
. 2001 Mar;
15(4):455-66.
PMID: 11230153
Hepatitis B, one of the most common infectious diseases in the world, is closely associated with acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Many clinical investigations have revealed that...
6.
Chacko B, Qin B, Correia J, Lam S, de Caestecker M, Lin K
Nat Struct Biol
. 2001 Feb;
8(3):248-53.
PMID: 11224571
Smad proteins mediate the transforming growth factor beta responses. C-terminal phosphorylation of R-Smads leads to the recruitment of Smad4 and the formation of active signaling complexes. We investigated the mechanism...
7.
Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Parks W, et al.
Nat Cell Biol
. 2001 Jan;
2(12):915-21.
PMID: 11146656
Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells...
8.
Tsang M, Kim R, de Caestecker M, Kudoh T, Roberts A, Dawid I
Genesis
. 2000 Nov;
28(2):47-57.
PMID: 11064421
Bone morphogenetic proteins (BMP) are members of the TGFbeta superfamily of secreted factors with important regulatory functions during embryogenesis. We have isolated the zebrafish gene, nma, that encodes a protein...
9.
de Caestecker M, Piek E, Roberts A
J Natl Cancer Inst
. 2000 Sep;
92(17):1388-402.
PMID: 10974075
Signaling from transforming growth factor-beta (TGF-beta) through its unique transmembrane receptor serine-threonine kinases plays a complex role in carcinogenesis, having both tumor suppressor and oncogenic activities. Tumor cells often escape...
10.
Kim R, Wang D, Tsang M, Martin J, Huff C, de Caestecker M, et al.
Genes Dev
. 2000 Jul;
14(13):1605-16.
PMID: 10887155
Members of the transforming growth factor-beta superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-beta family ligands are mediated by Smad proteins. To understand the mechanism...