M O James
Overview
Explore the profile of M O James including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
415
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Recent Articles
1.
Gadagbui B, James M
Mar Environ Res
. 2001 Jul;
50(1-5):353-6.
PMID: 11460717
Previous studies suggested that dietary composition affected glutathione S-transferase (GST) activity in catfish intestine, and this activity varied along the intestine. In this study, catfish were fed a semi-purified diet...
2.
Van Den Hurk P, James M
Mar Environ Res
. 2001 Jul;
50(1-5):11-5.
PMID: 11460675
Intestinal metabolism plays a significant role in the bioavailability of ingested environmental toxicants. In this study, the potential for first pass, phase 2 biotransformation of benzo[a]pyrene-7,8-dihydrodiol (BaP-7,8-diol) in intestinal mucosa...
3.
James M, Tong Z, Venugopal C, Kleinow K
Drug Metab Dispos
. 2001 Apr;
29(5):721-8.
PMID: 11302939
The intestinal bioavailability and biotransformation of 3-hydroxybenzo(a)pyrene, a major metabolite of benzo(a)pyrene in many animal species, was investigated in an in situ isolated intestinal preparation from the channel catfish, and...
4.
Li C, James M
Toxicol Sci
. 2000 Aug;
57(1):75-86.
PMID: 10966513
The pharmacokinetics of [(3)H]-9-hydroxybenzo[a]pyrene (9-OH-BaP), a highly lipophilic primary metabolite of benzo(a)pyrene, were examined after intrapericardial (iv) or oral doses of 50 or 200 microg/kg to intermolt American lobsters, Homarus...
5.
Doi A, Lou Z, Holmes E, Li C, Venugopal C, James M, et al.
Toxicol Sci
. 2000 May;
55(1):85-96.
PMID: 10788563
Polychlorinated biphenyls are transferred in the diet along aquatic food chains. This study investigated the effect of dietary micelle composition and 3,4,3',4'-tetrachlorobiphenyl (TCB) exposure upon the subsequent systemic bioavailability and...
6.
Tong Z, James M
Arch Biochem Biophys
. 2000 Apr;
376(2):409-19.
PMID: 10775429
Cytosol from channel catfish liver and intestinal mucosa has high sulfotransferase activity with low concentrations of 3-, 7-, or 9-hydroxybenzo[a]pyrene. To further investigate this conjugation pathway, sulfotransferase activity toward 9-hydroxybenzo[a]pyrene...
7.
Gadagbui B, James M
J Biochem Mol Toxicol
. 2000 Mar;
14(3):148-54.
PMID: 10711630
There is evidence that glutathione conjugates are the major metabolites formed following systemic uptake of carcinogenic contaminants from the intestine. The effect of commercial diet versus a semi-purified diet on...
8.
Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry
Yan Z, Henderson G, James M, Stacpoole P
J Pharm Biomed Anal
. 2000 Mar;
19(3-4):309-18.
PMID: 10704096
Chloral hydrate (CH) is a widely used sedative. Its pharmacological and toxicological effects are directly related to its metabolism. Prior investigations of CH metabolism have been limited by the lack...
9.
Cornett R, James M, Henderson G, Cheung J, Shroads A, Stacpoole P
Biochem Biophys Res Commun
. 1999 Sep;
262(3):752-6.
PMID: 10471397
Dichloroacetate (DCA) inhibits its own metabolism and is converted to glyoxylate by glutathione S-transferase zeta (GSTz). GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate...
10.
James M, Boyle S
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
. 1999 Feb;
121(1-3):157-72.
PMID: 9972457
Since the last review of this topic, further insight has been gained into the presence and functions of cytochrome P450 proteins in the hepatopancreas and other organs of aquatic crustacean...