M M Georgescu
Overview
Explore the profile of M M Georgescu including associated specialties, affiliations and a list of published articles.
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19
Citations
1506
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Recent Articles
1.
Yokoyama T, Iwado E, Kondo Y, Aoki H, Hayashi Y, Georgescu M, et al.
Gene Ther
. 2008 Jun;
15(17):1233-9.
PMID: 18580968
Oncolytic adenoviruses are a promising tool in cancer therapy. In this study, we characterized the role of autophagy in oncolytic adenovirus-induced therapeutic effects. OBP-405, an oncolytic adenovirus regulated by the...
2.
Shishido T, Akagi T, Chalmers A, Maeda M, Terada T, Georgescu M, et al.
Genes Cells
. 2001 May;
6(5):431-40.
PMID: 11380621
Background: c-Abl kinase is activated in response to a variety of biological stimuli. Crk family adaptor proteins can interact physically with c-Abl and be involved in the activation of c-Abl...
3.
Georgescu M, Kirsch K, Kaloudis P, Yang H, Pavletich N, Hanafusa H
Cancer Res
. 2001 Jan;
60(24):7033-8.
PMID: 11156408
PTEN is a tumor suppressor frequently inactivated in brain, prostate, and uterine cancer. It acts as a phosphoinositide phosphatase and consists of an amino-terminal phosphatase domain tightly linked to a...
4.
Kirsch K, Georgescu M, Shishido T, Langdon W, Birge R, Hanafusa H
J Biol Chem
. 2000 Nov;
276(7):4957-63.
PMID: 11067845
CMS/CD2AP is a cytoplasmic protein critical for the integrity of the kidney glomerular filtration and the T cell function. CMS contains domains and motifs characteristic for protein-protein interactions, and it...
5.
Shishido T, Akagi T, Ouchi T, Georgescu M, Langdon W, Hanafusa H
Proc Natl Acad Sci U S A
. 2000 Jun;
97(12):6439-44.
PMID: 10829062
The kinase activity of Abl is known to be regulated by a putative trans-acting inhibitor molecule interacting with the Src homology (SH) 3 domain of Abl. Here we report that...
6.
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu M, et al.
Cancer Res
. 2000 Apr;
60(6):1541-5.
PMID: 10749120
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein (FRAP) occurs via autocrine stimulation or inactivation of the tumor...
7.
Lee J, Yang H, Georgescu M, Di Cristofano A, Maehama T, Shi Y, et al.
Cell
. 1999 Nov;
99(3):323-34.
PMID: 10555148
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and phosphoinositide substrates in...
8.
Georgescu M, Kirsch K, Akagi T, Shishido T, Hanafusa H
Proc Natl Acad Sci U S A
. 1999 Sep;
96(18):10182-7.
PMID: 10468583
PTEN is a recently identified tumor suppressor inactivated in a variety of cancers such as glioblastoma and endometrial and prostate carcinoma. It contains an amino-terminal phosphatase domain and acts as...
9.
Kirsch K, Georgescu M, Ishimaru S, Hanafusa H
Proc Natl Acad Sci U S A
. 1999 May;
96(11):6211-6.
PMID: 10339567
Cas ligand with multiple Src homology (SH) 3 domains (CMS) is an ubiquitously expressed signal transduction molecule that interacts with the focal adhesion protein p130(Cas). CMS contains three SH3 in...
10.
Georgescu M, Kirsch K, Shishido T, Zong C, Hanafusa H
Mol Cell Biol
. 1999 Jan;
19(2):1171-81.
PMID: 9891051
The c-Mer receptor tyrosine kinase (RTK) is most closely related to chicken c-Eyk and belongs to the Axl RTK subfamily. Although not detected in normal lymphocytes, c-Mer is expressed in...