M L Brader
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Explore the profile of M L Brader including associated specialties, affiliations and a list of published articles.
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12
Citations
135
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Recent Articles
1.
Structural studies of a crystalline insulin analog complex with protamine by atomic force microscopy
Yip C, Brader M, Frank B, DeFelippis M, Ward M
Biophys J
. 2000 Jan;
78(1):466-73.
PMID: 10620310
Crystallographic studies of insulin-protamine complexes, such as neutral protamine Hagedorn (NPH) insulin, have been hampered by high crystal solvent content, small crystal dimensions, and extensive disorder in the protamine molecules....
2.
Yip C, DeFelippis M, Frank B, Brader M, Ward M
Biophys J
. 1998 Sep;
75(3):1172-9.
PMID: 9726919
Although x-ray crystal structures exist for many forms of insulin, the hormone involved in glucose metabolism and used in the treatment of diabetes, x-ray structural characterization of therapeutically important long-acting...
3.
Yip C, Brader M, DeFelippis M, Ward M
Biophys J
. 1998 May;
74(5):2199-209.
PMID: 9591647
The self-association of proteins is influenced by amino acid sequence, molecular conformation, and the presence of molecular additives. In the presence of phenolic additives, LysB28ProB29 insulin, in which the C-terminal...
4.
Clodfelter D, Pekar A, Rebhun D, Destrampe K, Havel H, Myers S, et al.
Pharm Res
. 1998 Apr;
15(2):254-62.
PMID: 9523312
Purpose: To utilize an acylated peptide as a model system to investigate the relationships among solution peptide conformation, non-covalent self-association, subcutaneous absorption and bioavailability under pharmaceutically relevant solution formulation conditions....
5.
Brader M, Kaarsholm N, Harnung S, Dunn M
J Biol Chem
. 1997 Jan;
272(2):1088-94.
PMID: 8995407
Magnetic circular dichroism (MCD) spectra of a series of adducts formed by the Co(II)-substituted R-state insulin hexamer are reported. The His-B10 residues in this hexamer form tris imidazole chelates in...
6.
Bakaysa D, Radziuk J, Havel H, Brader M, Li S, Dodd S, et al.
Protein Sci
. 1996 Dec;
5(12):2521-31.
PMID: 8976561
The rate-limiting step for the absorption of insulin solutions after subcutaneous injection is considered to be the dissociation of self-associated hexamers to monomers. To accelerate this absorption process, insulin analogues...
7.
Choi W, Brader M, Aguilar V, Kaarsholm N, Dunn M
Biochemistry
. 1993 Nov;
32(43):11638-45.
PMID: 8218231
The allosteric behavior of the Co(II)-substituted insulin hexamer has been investigated using electronic spectroscopy to study the binding of different phenolic analogues and singly charged anions to effector sites on...
8.
Brader M, Borchardt D, Dunn M
Biochemistry
. 1992 May;
31(19):4691-6.
PMID: 1316158
The R-state conformation of the Cu(II)-substituted insulin hexamer has been identified, and a number of its derivatives have been studied via 1H NMR, ESR, and UV-visible spectroscopy. This work establishes...
9.
Brader M, Dunn M
Trends Biochem Sci
. 1991 Sep;
16(9):341-5.
PMID: 1949156
Recent studies on the structural and chemical properties of insulin have shown that the insulin hexamer is an allosteric protein capable of adopting three distinct conformations, designated T6, T3R3 and...
10.
Brader M, Kaarsholm N, Lee R, Dunn M
Biochemistry
. 1991 Jul;
30(27):6636-45.
PMID: 2065051
1H NMR and UV-visible electronic absorption studies have been performed to investigate the effects of anions and cyclic organic molecules on the interconversion of the T- and R-conformational states (Kaarsholm...