A H Pekar
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Explore the profile of A H Pekar including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
192
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Recent Articles
1.
Clodfelter D, Pekar A, Rebhun D, Destrampe K, Havel H, Myers S, et al.
Pharm Res
. 1998 Apr;
15(2):254-62.
PMID: 9523312
Purpose: To utilize an acylated peptide as a model system to investigate the relationships among solution peptide conformation, non-covalent self-association, subcutaneous absorption and bioavailability under pharmaceutically relevant solution formulation conditions....
2.
Bakaysa D, Radziuk J, Havel H, Brader M, Li S, Dodd S, et al.
Protein Sci
. 1996 Dec;
5(12):2521-31.
PMID: 8976561
The rate-limiting step for the absorption of insulin solutions after subcutaneous injection is considered to be the dissociation of self-associated hexamers to monomers. To accelerate this absorption process, insulin analogues...
3.
Needham G, Pekar A, Havel H
J Pharm Sci
. 1995 Apr;
84(4):437-42.
PMID: 7629733
Optical spectroscopic methods (circular dichroism, analytical ultracentrifugation, and static light scattering) were employed to study the solution behavior of an N-terminal-acylated 76-residue analog of growth hormone releasing hormone (GHRH). The...
4.
Bryant C, Spencer D, Miller A, Bakaysa D, McCune K, Maple S, et al.
Biochemistry
. 1993 Aug;
32(32):8075-82.
PMID: 8394123
The effect of pH on the conformational stability of insulin was studied. Surprisingly, the Gibbs free energy of unfolding increased approximately 30% by acidification. pH titration of insulin's conformational stability...
5.
DeFelippis M, Alter L, Pekar A, Havel H, Brems D
Biochemistry
. 1993 Feb;
32(6):1555-62.
PMID: 8431435
It has been previously shown, by equilibrium denaturation, that human growth hormone (hGH) folds by a cooperative two-state process. This is in contrast to the folding pathways of other nonhuman...
6.
Brems D, Alter L, Beckage M, CHANCE R, DiMarchi R, Green L, et al.
Protein Eng
. 1992 Sep;
5(6):527-33.
PMID: 1438163
The importance of ProB28 and LysB29 on the self-association of insulin was established by systematically truncating the C terminus of the B chain. The relationship between structure and association was...
7.
Bryant C, Strohl M, Green L, Long H, Alter L, Pekar A, et al.
Biochemistry
. 1992 Jun;
31(25):5692-8.
PMID: 1610818
To determine the conformational properties of the C-terminal region of the insulin B-chain relative to the helical core of the molecule, we have investigated the fluorescence properties of an insulin...
8.
Tillil H, Frank B, Pekar A, Broelsch C, Rubenstein A, Polonsky K
Endocrinology
. 1990 Nov;
127(5):2418-22.
PMID: 2226325
Since circulating proinsulin has been suggested to be important in the pathogenesis of noninsulin-dependent diabetes, and biosynthetic human proinsulin (HPI) may have a therapeutic role in patients with diabetes mellitus,...
9.
Frank B, Pekar A, Pettee J, Schirmer E, Johnson M, CHANCE R
Int J Pept Protein Res
. 1984 May;
23(5):506-15.
PMID: 6735590
A genetic variant of bovine proinsulin has been isolated using preparative reverse-phase HPLC. The new proinsulin (bovine proinsulin II) differs from the known proinsulin (bovine proinsulin I) by a single...
10.