M J Sutcliffe
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Explore the profile of M J Sutcliffe including associated specialties, affiliations and a list of published articles.
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91
Citations
1506
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Recent Articles
1.
Ashmole I, Vavoulis D, Stansfeld P, Mehta P, Feng J, Sutcliffe M, et al.
J Physiol
. 2009 Aug;
587(Pt 20):4769-83.
PMID: 19703964
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the...
2.
McLaughlin L, Niazi U, Bibby J, David J, Vontas J, Hemingway J, et al.
Insect Mol Biol
. 2008 Mar;
17(2):125-35.
PMID: 18353102
Three CYP6Z genes are linked to a major pyrethroid resistance locus in the mosquito Anopheles gambiae. We have expressed CYP6Z2 in Escherichia coli and produced a structural model in order...
3.
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions
Marechal J, Kemp C, Roberts G, Paine M, Wolf C, Sutcliffe M
Br J Pharmacol
. 2007 Nov;
153 Suppl 1:S82-9.
PMID: 18026129
The cytochromes P450 (CYPs) comprise a vast superfamily of enzymes found in virtually all life forms. In mammals, xenobiotic metabolizing CYPs provide crucial protection from the effects of exposure to...
4.
Yuill K, Stansfeld P, Ashmole I, Sutcliffe M, Stanfield P
Pflugers Arch
. 2007 Jun;
455(2):333-48.
PMID: 17541788
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1....
5.
McLean K, Sabri M, Marshall K, Lawson R, Lewis D, Clift D, et al.
Biochem Soc Trans
. 2005 Jul;
33(Pt 4):796-801.
PMID: 16042601
P450s (cytochrome P450 mono-oxygenases) are a superfamily of haem-containing mono-oxygenase enzymes that participate in a wide range of biochemical pathways in different organisms from all of the domains of life....
6.
Rigby S, Basran J, Combe J, Mohsen A, Toogood H, van Thiel A, et al.
Biochem Soc Trans
. 2005 Jul;
33(Pt 4):754-7.
PMID: 16042592
Amines are a carbon source for the growth of a number of bacterial species and they also play key roles in neurotransmission, cell growth and differentiation, and neoplastic cell proliferation....
7.
Sutcliffe M, Shuster J, Sather H, Camitta B, Pullen J, Schultz K, et al.
Leukemia
. 2005 Mar;
19(5):734-40.
PMID: 15789069
Chromosome aberrations have a major role in pediatric acute lymphoblastic leukemia (ALL) risk assignment. The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG) independently assessed the significance of...
8.
Munro A, McLean K, Marshall K, Warman A, Lewis G, Roitel O, et al.
Biochem Soc Trans
. 2003 May;
31(Pt 3):625-30.
PMID: 12773169
Novel drug strategies are desperately needed to combat the global threat posed by multidrug-resistant strains of Mycobacterium tuberculosis (Mtb). The genome sequence of Mtb has revealed an unprecedented number of...
9.
Basran J, Sutcliffe M, Scrutton N
J Biol Chem
. 2001 Sep;
276(46):42887-92.
PMID: 11553643
Recent evidence from isotope studies supports the view that catalysis by trimethylamine dehydrogenase (TMADH) proceeds from a Michaelis complex involving trimethylamine base and not, as thought previously, trimethylammonium cation. In...
10.
Faulder P, Tresadern G, Chohan K, Scrutton N, Sutcliffe M, Hillier I, et al.
J Am Chem Soc
. 2001 Aug;
123(35):8604-5.
PMID: 11525672
No abstract available.