M J Blackman
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Explore the profile of M J Blackman including associated specialties, affiliations and a list of published articles.
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40
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1593
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Recent Articles
11.
Egan A, Blackman M, Kaslow D
Infect Immun
. 2000 Feb;
68(3):1418-27.
PMID: 10678955
Protection against a lethal challenge infection of Plasmodium falciparum was elicited in malaria-naive Aotus vociferans monkeys by vaccination with the C terminus 19-kDa protein of the major merozoite surface protein...
12.
Sajid M, Blackman M
J Biol Chem
. 2000 Jan;
275(1):631-41.
PMID: 10617661
Plasmodium falciparum subtilisin-like protease-1 (PfSUB-1) is a protein belonging to the subtilisin-like superfamily of serine proteases (subtilases). PfSUB-1 undergoes extensive posttranslational proteolytic processing. The primary translation product is converted in...
13.
Carpenter E, Hackett F, Ely B, Sajid M, Grainger M, Blackman M
Protein Eng
. 1999 Dec;
12(12):1113-20.
PMID: 10611405
The A+T-rich genome of the human malaria parasite Plasmodium falciparum encodes genes of biological importance that cannot be expressed efficiently in heterologous eukaryotic systems, owing to an extremely biased codon...
14.
Hackett F, Sajid M, Grainger M, Blackman M
Mol Biochem Parasitol
. 1999 Nov;
103(2):183-95.
PMID: 10551362
Erythrocyte invasion by the malaria merozoite requires the activity of merozoite proteases. We have previously identified a Plasmodium falciparum protein belonging to the superfamily of subtilisin-like serine proteases, which is...
15.
Blackman M, Fujioka H, STAFFORD W, Sajid M, Clough B, Fleck S, et al.
J Biol Chem
. 1998 Aug;
273(36):23398-409.
PMID: 9722575
In the vertebrate host, the malaria parasite invades and replicates asexually within circulating erythrocytes. Parasite proteolytic enzymes play an essential but poorly understood role in erythrocyte invasion. We have identified...
16.
Spencer Valero L, Ogun S, Fleck S, Ling I, Blackman M, Holder A
Infect Immun
. 1998 Jul;
66(8):3925-30.
PMID: 9673281
We have produced monoclonal antibodies against Plasmodium yoelii merozoite surface protein 1 (MSP-1) and have assessed their ability to suppress blood stage parasitemia by passive immunization. Six immunoglobulin G antibodies...
17.
Guevara Patino J, Holder A, McBride J, Blackman M
J Exp Med
. 1997 Dec;
186(10):1689-99.
PMID: 9362529
Merozoite surface protein-1 (MSP-1) of the human malaria parasite Plasmodium falciparum undergoes at least two endoproteolytic cleavage events during merozoite maturation and release, and erythrocyte invasion. We have previously demonstrated...
18.
Zinecker C, Gerold P, Azzouz N, Striepen B, Schmidt A, Berhe S, et al.
Indian J Biochem Biophys
. 1997 Feb;
34(1-2):105-9.
PMID: 9343937
We are investigating the structure and biosynthesis of glycosyl-phosphatidylinositols (GPI) in the protozoa Toxoplasma gondii, Plasmodium falciparum, Plasmodium yoelii and Paramecium primaurelia. This comparison of structural and biosynthesis data should...
19.
STAFFORD W, Gunder B, Harris A, HEIDRICH H, Holder A, Blackman M
Mol Biochem Parasitol
. 1996 Oct;
80(2):159-69.
PMID: 8892293
The Plasmodium falciparum merozoite surface protein-1 (MSP-1) is synthesized as a precursor of approximately 195 kDa and is processed to form a complex of polypeptides on the surface of free...
20.
Blackman M, Dennis E, Hirst E, Kocken C, Thomas A
Exp Parasitol
. 1996 Jul;
83(2):229-39.
PMID: 8682191
Secondary processing of the Plasmodium falciparum malaria merozoite surface protein-1 (MSP-1) is defined as a single proteolytic cleavage within the carboxy-terminal membrane-bound component of the MSP-1 protein complex on the...