M J Bickerdike
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Explore the profile of M J Bickerdike including associated specialties, affiliations and a list of published articles.
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13
Citations
215
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Recent Articles
1.
Richter H, Adams D, Benardeau A, Bickerdike M, Bentley J, Blench T, et al.
Bioorg Med Chem Lett
. 2005 Dec;
16(5):1207-11.
PMID: 16361098
Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of 5,5a,6,7,8,9-hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines culminating in the discovery of (5aR,9R)-2-[(cyclopropylmethoxy)methyl]-5,5a,6,7,8,9-hexahydro-9-methyl-pyrido[3', 2':4,5]pyrrolo[1,2-a]pyrazine 18 as a potent, full 5-HT(2C) receptor agonist...
2.
Rover S, Adams D, Benardeau A, Bentley J, Bickerdike M, Bourson A, et al.
Bioorg Med Chem Lett
. 2005 Jun;
15(15):3604-8.
PMID: 15975787
Synthesis and evaluation of the activity of new 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT(2C) receptor agonists are described. Appropriately substituted, several analogs displayed selectivity against the other 5-HT(2) receptor subtypes of 1 order...
3.
Bentley J, Adams D, Bebbington D, Benwell K, Bickerdike M, Davidson J, et al.
Bioorg Med Chem Lett
. 2004 Apr;
14(9):2367-70.
PMID: 15081042
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional...
4.
Vickers S, Easton N, Webster L, Wyatt A, Bickerdike M, Dourish C, et al.
Psychopharmacology (Berl)
. 2003 Apr;
167(3):274-80.
PMID: 12690422
Rationale: The 5-HT(2C) receptor subtype has been implicated extensively in the regulation of ingestive behaviour. Objective: To assess whether chronic administration of the preferential 5-HT(2C) receptor agonist, mCPP, reduces rat...
5.
Stanhope K, Mirza N, Bickerdike M, Bright J, Harrington N, Hesselink M, et al.
J Pharmacol Exp Ther
. 2001 Oct;
299(2):782-92.
PMID: 11602695
The muscarinic receptor agonist xanomeline was examined and compared with the antipsychotics clozapine and/or haloperidol in the following in vivo rat models: apomorphine-induced disruption of prepulse inhibition (PPI), amphetamine-induced hyperlocomotion,...
6.
Vickers S, Easton N, Malcolm C, Allen N, Porter R, Bickerdike M, et al.
Pharmacol Biochem Behav
. 2001 Aug;
69(3-4):643-52.
PMID: 11509227
The pharmacology of several commonly described 5-hydroxytryptamine (5-HT)(2C) receptor agonists was investigated in vivo and in vitro at rat 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors. The 5-HT(2C) receptor agonist, (S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine fumarate...
7.
Bickerdike M, Vickers S, Dourish C
Diabetes Obes Metab
. 2001 Mar;
1(4):207-14.
PMID: 11228755
No abstract available.
8.
Vickers S, Benwell K, Porter R, Bickerdike M, Kennett G, Dourish C
Br J Pharmacol
. 2000 Jul;
130(6):1305-14.
PMID: 10903970
1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175...
9.
Bickerdike M, Abercrombie E
Neuroreport
. 1999 Mar;
10(1):77-80.
PMID: 10094137
Behavioral sensitization to chronic amphetamine develops in parallel with an enhancement of amphetamine-stimulated efflux of acetylcholine (ACh) in striatum. The present study investigated the role of NMDA receptors in the...
10.
Bickerdike M, Abercrombie E
J Pharmacol Exp Ther
. 1997 Aug;
282(2):818-26.
PMID: 9262346
Stimulant sensitization is defined as an enhancement of the behavioral response to drug after repeated drug exposure. We have examined the relation between the expression of behavioral sensitization and the...