M H Buonarati
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Explore the profile of M H Buonarati including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Helton D, Osborne D, Pierson S, Buonarati M, Bethem R
Drug Metab Dispos
. 2000 Jul;
28(8):925-9.
PMID: 10901702
Dapsone is a potent anti-inflammatory and antibacterial agent that has been used extensively in the oral treatment of leprosy and dermatitis herpetiformis. This study compared the pharmacokinetic profile of dapsone...
2.
Snyderwine E, Turesky R, Buonarati M, Turteltaub K, Adamson R
Princess Takamatsu Symp
. 1995 Jan;
23:69-77.
PMID: 8844797
The metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), three heterocyclic amine mutagens and carcinogens derived from cooked food, was examined in cynomolgus monkeys. IQ is...
3.
Malfatti M, Buonarati M, Turteltaub K, Shen N, FELTON J
Chem Res Toxicol
. 1994 Mar;
7(2):139-47.
PMID: 8199301
Mutagenic activity of the cooked-food mutagen/carcinogen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) is highly dependent upon cytochrome P450 activation to the N-hydroxylated intermediate. In the present study the bioactivation pathways of PhIP were investigated...
4.
Snyderwine E, Buonarati M, FELTON J, Turteltaub K
Carcinogenesis
. 1993 Dec;
14(12):2517-22.
PMID: 8269621
Metabolism of the food-derived heterocyclic amine mutagen/carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was examined in cynomolgus monkeys. [3H]PhIP (50 mumol/kg, p.o.) was extensively metabolized, with only 1% of the dose excreted into the...
5.
Turteltaub K, Vogel J, Frantz C, Buonarati M, FELTON J
Environ Health Perspect
. 1993 Mar;
99:183-6.
PMID: 8319619
The bioavailability and the bioreactivity of the carcinogenic heterocyclic amine [2-14C]2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) have been investigated at a dose approximating that likely from the human diet by accelerator mass spectrometry (AMS)....
6.
Jones A, Winter C, Buonarati M, Segall H
Biol Mass Spectrom
. 1993 Jan;
22(1):68-76.
PMID: 8431504
Mass spectra of mercapturic acid conjugates of two xenobiotic products of lipid peroxidation (trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal) as well as conjugates of 1,3-dichloropropene, styrene oxide, 1,2-naphthalene oxide and alpha-chlorotoluene were obtained...
7.
Buonarati M, Roper M, Morris C, Happe J, Knize M, FELTON J
Carcinogenesis
. 1992 Apr;
13(4):621-7.
PMID: 1576715
The metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), a heterocyclic amine carcinogen detected in cooked meats, was investigated in mice. In 3-methylcholanthrene-induced mice administered 0.1, 1.0 and 10 mg/kg [14C]PhIP (i.p.), urinary and...
8.
Buonarati M, Tucker J, MINKLER J, Wu R, Thompson L, FELTON J
Mutagenesis
. 1991 Jul;
6(4):253-9.
PMID: 1943715
We have utilized Chinese hamster ovary cell lines which stably express a murine cytochrome P450IA2 (P(3)450) cDNA to characterize more fully the mechanisms of genotoxicity of heterocyclic amines derived from...
9.
DNA dosimetry following carcinogen exposure using accelerator mass spectrometry and 32P-postlabeling
FELTON J, Turteltaub K, Gledhill B, Vogel J, Buonarati M, Davis J
Prog Clin Biol Res
. 1991 Jan;
372:243-53.
PMID: 1956922
No abstract available.
10.
FELTON J, Knize M, Turteltaub K, Buonarati M, Taylor R, Vanderlaan M, et al.
Adv Exp Med Biol
. 1991 Jan;
289:133.
PMID: 1897388
No abstract available.