M E Shuck
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Explore the profile of M E Shuck including associated specialties, affiliations and a list of published articles.
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13
Citations
870
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Recent Articles
1.
Emmons T, Shuck M, Babcock M, Holloway J, Leone J, Durbin J, et al.
Protein Pept Lett
. 2008 Feb;
15(2):119-30.
PMID: 18289104
BACE, or beta-secretase, is an attractive target in the treatment of Alzheimer's Disease because of its involvement in the generation of amyloid beta peptides. BACE is a type I transmembrane...
2.
Yan R, Munzner J, Shuck M, Bienkowski M
J Biol Chem
. 2001 Jun;
276(36):34019-27.
PMID: 11423558
BACE1 and BACE2 define a new subfamily of membrane-anchored aspartyl proteases. Both endoproteases share similar structural organization including a prodomain, a catalytic domain formed via DTG and DSG active site...
3.
Roberds S, Anderson J, Basi G, Bienkowski M, Branstetter D, Chen K, et al.
Hum Mol Genet
. 2001 Jun;
10(12):1317-24.
PMID: 11406613
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, beta-amyloid peptides (Abetas), are produced from...
4.
Yan R, Bienkowski M, Shuck M, Miao H, Tory M, Pauley A, et al.
Nature
. 1999 Dec;
402(6761):533-7.
PMID: 10591213
Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheimer's disease. Cleavage of APP by unidentified proteases, referred to as beta- and gamma-secretases, generates the amyloid...
5.
Bock J, Shuck M, Benjamin C, CHEE M, Bienkowski M, Slightom J
Gene
. 1997 Mar;
188(1):9-16.
PMID: 9099852
Detailed analyses of transcripts encoding various isoforms of the human potassium (K+, inward rectifying) channel ROM-K (also referred to as K(ir)1.1) revealed the existence of at least five distinct transcripts...
6.
Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions
Jenkins J, Drong R, Shuck M, Bienkowski M, Slightom J, Arend W, et al.
J Immunol
. 1997 Jan;
158(2):748-55.
PMID: 8992991
The objective of these studies was to examine the molecular mechanisms involved in transcriptional regulation of the gene for the intracellular structural variant of the IL-1 receptor antagonist (icIL-1Ra) molecule....
7.
Shuck M, Piser T, Bock J, Slightom J, Lee K, Bienkowski M
J Biol Chem
. 1997 Jan;
272(1):586-93.
PMID: 8995301
The DNA sequence encoding the rat brain inward rectifier-10 K+ channel was amplified from rat brain RNA using reverse transcription-polymerase chain reaction and used to clone the human homolog. Low...
8.
ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms
Boim M, Ho K, Shuck M, Bienkowski M, BLOCK J, Slightom J, et al.
Am J Physiol
. 1995 Jun;
268(6 Pt 2):F1132-40.
PMID: 7611454
The rat ROMK gene encodes inwardly rectifying, ATP-regulated K+ channels [K. Ho, C. G. Nichols, W. J. Lederer, J. Lytton, P. M. Vassilev, M. V. Kanazirska, and S. C. Hebert....
9.
Tsai T, Shuck M, Thompson D, Bienkowski M, Lee K
Am J Physiol
. 1995 May;
268(5 Pt 1):C1173-8.
PMID: 7762610
The pH sensitivity of a cloned rat kidney K+ channel, ROMK1, was examined after expression in Xenopus oocytes. Membrane currents and intracellular pH (pHi) were concomitantly monitored by the two-microelectrode...
10.
McCall R, Romero A, Bienkowski M, Harris D, McGUIRE J, Piercey M, et al.
J Pharmacol Exp Ther
. 1994 Nov;
271(2):875-83.
PMID: 7965808
The purpose of the present study was to characterize U-92016A [(+)-R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro-3H-benz[e] indole] as a 5-hydroxytryptamine (5-HT)1A receptor agonist and to compare its activity with that of standard 5-HT1A receptor agonists....