M E Selsted
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Explore the profile of M E Selsted including associated specialties, affiliations and a list of published articles.
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103
Citations
5363
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Recent Articles
1.
Chong-Cerrillo C, Selsted M, Peterson E, de la Maza L
J Pept Res
. 2003 Mar;
61(5):237-42.
PMID: 12662357
Four antimicrobial peptides, protegrin-1, RTD-1, cryptdin-4, and indolicidin, were tested for their ability to inhibit the in vitro growth of Chlamydia trachomatis serovars E, L2, and mouse pneumonitis (MoPn). In...
2.
Ayabe T, Satchell D, Wilson C, Parks W, Selsted M, Ouellette A
Nat Immunol
. 2001 Mar;
1(2):113-8.
PMID: 11248802
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and alpha-defensins, or cryptdins,...
3.
Merlin D, Yue G, Lencer W, Selsted M, Madara J
Am J Physiol Cell Physiol
. 2001 Feb;
280(2):C296-302.
PMID: 11208524
Opening of anion-conductive pathways in apical membranes of secretory cells lining mucosal surfaces is a critical step in salt and water secretion and, thus, hydration of sites including airway and...
4.
Mambula S, Simons E, Hastey R, Selsted M, Levitz S
Infect Immun
. 2000 Oct;
68(11):6257-64.
PMID: 11035733
It has long been appreciated that polymorphonuclear leukocytes (PMN) kill Cryptococcus neoformans, at least in part via generation of fungicidal oxidants. The aim of this study was to examine the...
5.
Newman S, Gootee L, Gabay J, Selsted M
Infect Immun
. 2000 Sep;
68(10):5668-72.
PMID: 10992469
Previously we demonstrated that human neutrophils mediate potent and long-lasting fungistasis against Histoplasma capsulatum yeasts and that all of the fungistatic activity resides in the azurophil granules. In the present...
6.
Ouellette A, Satchell D, Hsieh M, Hagen S, Selsted M
J Biol Chem
. 2000 Aug;
275(43):33969-73.
PMID: 10942762
Paneth cells at the base of small intestinal crypts secrete apical granules that contain antimicrobial peptides including alpha-defensins, termed cryptdins. Using an antibody specific for mouse cryptdin-1, -2, -3, and...
7.
Osapay K, Tran D, Ladokhin A, White S, Henschen A, Selsted M
J Biol Chem
. 2000 Apr;
275(16):12017-22.
PMID: 10766833
Indolicidin is a 13-residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The unique composition of indolicidin distinguishes it from alpha-helical and beta-structured cationic peptides, because five...
8.
Ouellette A, Darmoul D, Tran D, Huttner K, Yuan J, Selsted M
Infect Immun
. 1999 Nov;
67(12):6643-51.
PMID: 10569786
Paneth cells in crypts of the small intestine express antimicrobial peptides, including alpha-defensins, termed cryptdins in mice. Of the known Paneth cell alpha-defensins, the cryptdin 4 gene is unique, because...
9.
Tang Y, Yuan J, Miller C, Selsted M
Infect Immun
. 1999 Oct;
67(11):6139-44.
PMID: 10531277
Experiments to isolate and characterize rhesus macaque myeloid alpha-defensins (RMADs) were conducted. Seven RMAD peptides were isolated and sequenced, and the cDNAs encoding six of these peptides and one other...
10.
Tang Y, Yuan J, Osapay G, Osapay K, Tran D, Miller C, et al.
Science
. 1999 Oct;
286(5439):498-502.
PMID: 10521339
Analysis of rhesus macaque leukocytes disclosed the presence of an 18-residue macrocyclic, tridisulfide antibiotic peptide in granules of neutrophils and monocytes. The peptide, termed rhesus theta defensin-1 (RTD-1), is microbicidal...