M E Ewen
Overview
Explore the profile of M E Ewen including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
3018
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0
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Recent Articles
1.
Kitajima S, Yoshida A, Kohno S, Li F, Suzuki S, Nagatani N, et al.
Oncogene
. 2017 May;
36(36):5145-5157.
PMID: 28481867
Retinoblastoma (RB) protein inactivation during tumor progression is often associated with acquisition of immature phenotypes and resistance to therapy. Determination of an RB inactivation signature in a context of gaining...
2.
Lamb J, Ladha M, McMahon C, Sutherland R, Ewen M
Mol Cell Biol
. 2000 Nov;
20(23):8667-75.
PMID: 11073968
We report that the functional interaction between cyclin D1 and the estrogen receptor (ER) is regulated by a signal transduction pathway involving the second messenger, cyclic AMP (cAMP). The cell-permeable...
3.
Miller S, Suthiphongchai T, Zambetti G, Ewen M
Mol Cell Biol
. 2000 Oct;
20(22):8420-31.
PMID: 11046139
One consequence of transforming growth factor beta (TGF-beta) treatment is inhibition of Cdk4 synthesis, and this is dependent on p53. Here, we show that the 5' untranslated region (UTR) of...
4.
5.
Vairo G, Soos T, Upton T, Zalvide J, DeCaprio J, Ewen M, et al.
Mol Cell Biol
. 2000 Jun;
20(13):4745-53.
PMID: 10848600
Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism, retard entry into the cell cycle. Cell cycle progression requires the phosphorylation by cyclin-dependent kinases (Cdks) of retinoblastoma protein...
6.
Ewen M
Prog Cell Cycle Res
. 2000 Mar;
4:1-17.
PMID: 10740810
The ordered execution of the two main events of cellular reproduction, duplication of the genome and cell division, characterize progression through the cell cycle. Cultured cells can be switched between...
7.
Lee K, Ladha M, McMahon C, Ewen M
Mol Cell Biol
. 1999 Oct;
19(11):7724-32.
PMID: 10523661
The inner membrane-bound protein Ras integrates various extracellular signals that are subsequently communicated from the cytoplasm to the nucleus via the Raf/MEK/MAPK cascade. Here we show that the retinoblastoma protein...
8.
McMahon C, Suthiphongchai T, DiRenzo J, Ewen M
Proc Natl Acad Sci U S A
. 1999 May;
96(10):5382-7.
PMID: 10318892
Cyclin D1 is overexpressed in a significant percentage of human breast cancers, particularly in those that also express the estrogen receptor (ER). We and others have demonstrated previously that experimentally...
9.
Reed M, Liu V, Ladha M, Ando K, Griffin J, Weaver D, et al.
Oncogene
. 1999 Jan;
17(23):2961-71.
PMID: 9881698
In hematopoietic cells, gamma-irradiation causes a p53-dependent transient G1 phase cell cycle arrest. Various extracellular growth inhibitory signals elicit G1 arrest by targeting CDK4. Here we show that in a...
10.
Ladha M, Lee K, Upton T, Reed M, Ewen M
Mol Cell Biol
. 1998 Oct;
18(11):6605-15.
PMID: 9774675
The synthesis of cyclin D1 and its assembly with cyclin-dependent kinase 4 (CDK4) to form an active complex is a rate-limiting step in progression through the G1 phase of the...