M D Weitzman
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Explore the profile of M D Weitzman including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1083
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Recent Articles
1.
Fleisig H, Orazio N, Liang H, Tyler A, Adams H, Weitzman M, et al.
Oncogene
. 2007 Feb;
26(33):4797-805.
PMID: 17311003
Sequence-specific single-stranded DNA-binding protein 2 (SSBP2) is a candidate tumor suppressor for human acute myelogenous leukemia (AML). Inducible expression of SSBP2 causes growth arrest and partial differentiation in AML cells....
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Cathomen T, Stracker T, Gilbert L, Weitzman M
Proc Natl Acad Sci U S A
. 2001 Dec;
98(26):14991-6.
PMID: 11734633
Adeno-associated virus type 2 (AAV2) is a human parvovirus that has attracted attention as a vector for gene transfer. Replication and site-specific integration of the wild-type virus requires binding of...
4.
Grifman M, Trepel M, Speece P, Gilbert L, Arap W, Pasqualini R, et al.
Mol Ther
. 2001 Jun;
3(6):964-75.
PMID: 11407911
The human parvovirus adeno-associated virus type 2 (AAV-2) possesses many features that make it an attractive vector for gene delivery in vivo. However, its broad host range may limit its...
5.
Cathomen T, Weitzman M
J Virol
. 2000 Nov;
74(23):11407-12.
PMID: 11070042
In adenovirus-infected cells, binding of E1B-55kDa and E4orf6 to the tumor suppressor protein p53 inhibits its transcriptional activity and causes rapid turnover of the protein. To investigate the requirements of...
6.
Trepel M, Grifman M, Weitzman M, Pasqualini R
Hum Gene Ther
. 2000 Oct;
11(14):1971-81.
PMID: 11020797
Gene therapy would be considerably more effective if vectors could be targeted to specific organs or tissues after systemic administration. We previously developed an in vivo selection system to isolate...
7.
Cathomen T, Collete D, Weitzman M
J Virol
. 2000 Feb;
74(5):2372-82.
PMID: 10666268
The Rep78 and Rep68 proteins of adeno-associated virus (AAV) type 2 are involved in DNA replication, regulation of gene expression, and targeting site-specific integration. They bind to a specific Rep...
8.
Grifman M, Chen N, Gao G, Cathomen T, Wilson J, Weitzman M
J Virol
. 1999 Nov;
73(12):10010-9.
PMID: 10559315
The 34-kDa product of adenovirus E4 region open reading frame 6 (E4orf6) dramatically enhances transduction by recombinant adeno-associated virus vectors (rAAV). This is achieved by promoting the conversion of incoming...
9.
Loeb J, Cordier W, Harris M, Weitzman M, Hope T
Hum Gene Ther
. 1999 Oct;
10(14):2295-305.
PMID: 10515449
The woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) evolved to stimulate the expression of intronless viral messages. To determine whether this ability to enhance expression could be useful in nonviral...
10.
Parry S, Holder J, Halterman M, Weitzman M, Davis A, Federoff H, et al.
Am J Pathol
. 1998 Jun;
152(6):1521-9.
PMID: 9626056
We investigated the transfer of the lacZ reporter gene into human trophoblastic cells using herpes simplex virus and adeno-associated virus vectors. We used an established choriocarcinoma cell line (BeWo cells)...